期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

急性肺损伤时肺表面活性物质的变化及意义 被引量：3

Pulmonary Surfactant Alteration in Acute Iung injury
暂未订购
导出
摘要 急性肺损伤时肺的表面张力增高 ,肺表面活性物质 (pulmonarysurfactant ,PS)结构和功能发生改变 ,其原因包括血浆蛋白渗出液对PS的抑制作用 ,炎症介质、不适当机械通气等对PS的损伤 ,从而导致肺功能受损 ,易于形成肺水肿 ,肺部免疫防御能力降低 ,加重呼吸机诱发肺损伤的风险。大剂量外源性PS替代治疗有望降低急性肺损伤的病死率。
作者 龚小慧 孙波
机构地区 复旦大学附属儿科医院
出处 《国外医学（儿科学分册）》 2005年第1期34-36,共3页 Foreign Medical Sciences（Section of Pediatrics)
关键词 呼吸窘迫综合征 肺表面活性剂
分类号 R563.8 [医药卫生—呼吸系统]
  • 相关文献

参考文献19

  • 1Schmidt R, Meier U,Yabut-Perez M,et al. Alteration of fatty acid profiles in different pulmonary surfactant phospholipids in acute respiratory distress syndrome and severe pneumonia[J].Am J Respir Crit Care Med,2001,163(1) :95-100.
  • 2Maitra G, Inchley K, Novick RJ, et al. Acute lung injury and lung transplantation influence in vitro subtype conversion of pulmonary surfactant[J].Am J Physiol Lung Cell Mol Physiol,2002,282 (1) :L67-L74.
  • 3Fehrenbach H, Brasch F, Uhlig S, et al. Early alterations in intracellular and alveolar surfactant of the rat lung in response to endotoxin[J] .Am J Respir Crit Care Med, 1998,157 (5): 1630-1639.
  • 4Attalah HL, Wu Y,Alaoui-El-Azher M,et al. Induction of type-ILA secretory phospholipase A2 in animal models of acute lung injury[J]. Eur Respir J,2003,21 (6): 1040-1045.
  • 5Chabot S, Koumanov K, Lambeau G, et al. Inhibitory effects of surfactant protein A on surfactant phospholipid hydrolysis by secreted phospholipases A2[J] .J Immunol,2003,171 (2) :995-1000.
  • 6Mallampalli RK, Ryan AJ, Salome RG, et al. Tumor necrosis factor-alpha inhibits expression of GTP: phosphocholi ne cytidylyltransferase [ J ]. J Biol Chem,2000,275(13) :9699-9708.
  • 7Panda AK, Nag K, Harbottle RR, et al. Effect of acute lung injury on structure and function of pulmonary surfactant films[J]. Am J Respir Cell Mol Biol,2004,30(5) :641-650.
  • 8Veldhuizen RA,Welk B,Harbottle R,et al. Mechanical ventilation of isolated rat lungs changes the structure and biophysical properties of surfactant[J]. J Appl Physiol,2002,92(3): 1169-1175.
  • 9Kerr CL,Veldhuizen RA,Lewis JF. Effects of high-frequency oscillation on endogenous surfactant in an acute lung injury model[J]. Am J Respir Crit Care Med,2001,164(2) :237-242.
  • 10Tonks AJ, Tonks A, Morris RH, et al. Regulation of platelet-activating factor synthesis in human monocytes by dipalmitoyl phosphatidylcholine [ J ]. J Leukoc Biol,2003,74(1) :95-101.

同被引文献28

  • 1刘辉,王国军,丁正年.外源性肺泡表面活性物质对急性肺损伤治疗效果及量效关系的研究[J].南京医科大学学报（自然科学版）,2005,25(3):176-179. 被引量：5
  • 2高习文,修清玉.肺表面活性物质与急性呼吸窘迫综合征[J].国外医学（呼吸系统分册）,2005,25(6):471-472. 被引量：7
  • 3汪菠,孙波.肺表面活性物质与小儿急性肺损伤的临床研究进展[J].中国小儿急救医学,2007,14(2):96-99. 被引量：32
  • 4中华医学会呼吸病学分会.急性肺损伤／急性呼吸窘迫综合征的诊断标准（草案）[J].中华结核和呼吸杂志,2000,23(4):203-203.
  • 5Femando FV, Nicdos N, Anders E. Epidemiology of acute lung injury and acute respiratory distress syndrome. Cur Opin Crtic Care, 2004, 10(1):1 -6.
  • 6美国机动车医学促进会(Association for the Advancement of Automotive Medicine),编著.重庆市急救中心编译.简明损伤定级标准.重庆:重庆出版社,2002.30-130.
  • 7Murray JF, Matthay MA, Luce JM, et al. An expanded definition of adult respiratory distress syndrome. Am Rev Respir Dis, 1988, 138(3) :720 -723.
  • 8Mccormack FX, Whitsett JA. The pulmonary colletins, SP - Aand SP- D orchestrate innate immunity in the lung. J Clin Invest, 2002, 109(6) :707 -712.
  • 9Ikegami M, Na CL, Korlhagen TR, et al. Surfactant protein D influences surfactant ultrastructure and uptake by alveolar type Ⅱ cells. Am J Physiol Lung Cell Mol Physiol, 2005, 288 (3) : L552 - L561.
  • 10Eisner MD, Parsons P, Matthay MA, et al. Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury. Thorax, 2003, 58(11 ) :983 -988.

引证文献3

国外医学（儿科学分册）
2005年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部