摘要
研究目的探讨小儿频繁复发性肾病综合征的新疗法—Cyclophosphamide冲击疗法的作用研究背景环磷酰胺(Cyclophosphamide)冲击疗法治疗狼疮性肾炎近年日益受到国内外同道的关注并取得良效。小儿频繁复发性肾病综合征的治疗十分棘手。本文企图观察Cyclophosphamide冲击疗法对本症的作用,并进行评价。目前国内未见报道。处理方法 Cyclophosphamide 10mg/kg,每月1次,共9～12次,静脉点滴。设有对照组。两组均服强的松。治疗前、后一周查血常规、血小板、尿常规、每月查一次BUN、Cr、肝功能等。将结果进行四表格确切概率处理。结果治疗组7例,复发1例2次。对照组复发6例28次。经四表格确切概率计算,P<0.05。结论 Cyclophosphamide冲击疗法对小儿频繁复发性肾病综合征有良好作用。
Study Object The new therapy to frequent relapse of nephrotic syndrome in children-the effect of pulse therapy of Cyclophosphamide were explored.
Study background Recently it is being followed with interest day by day by the same trad at home and abroad that the patient with lupus nephritis were treated with pulse therapy of Cyclophosphamide and have had a good effect. The treatment of frequent relapse of nephrotic syndrome in children is very knotty. This object meant to observe and appraise the effect of pulse therapy of Cyclophosphamide to the disease. The home report hasn't been at present.
Methods Cyclophosphamide 10 mg/kg, every month, ivg11 for a period of 9-12 months. The control group were set up. All the two groups took prednisone. Routine blood and urine test, platelet count were detected a week before and behind the treatment, BUN, Cr, liver function every month. The result were handled with exact probability in 2 x 2 table.
Results 1 case had a relapse 2 times in the treatment group, 6 cases, 28 times in the control group. Calculated with exact probability in 2 x 2 table p= 0.028.
Conclusion The pulse therapy of Cyclophosphamide in frequent relapse of nephrotic syndrome in chilren had a good effect.
出处
《新乡医学院学报》
CAS
1993年第1期24-26,共3页
Journal of Xinxiang Medical University
关键词
环磷酰胺
冲击疗法
肾病综合征
cyclophosphamide, pulse therapy, nephrotic syndrome
