摘要
用小鼠的输血模型,研究了输血对受鼠 T 淋巴细胞的影响。实验发现,单次同种异品系间的输血,受血鼠的迟发型超敏反应和 ConA 诱导的淋巴细胞转化明显低于输生理盐水和同种同品系血组(P<0.05)。重复输血后抑制作用更加明显(P<0.01),并可使 T_H/Ts 比值下降,其原因是 Ts 细胞数量增多。结果提示,输血对 T 淋巴细胞的影响,与 H—2主要组织相容性复合体及输血次数有关。输血引起的 T 细胞功能下降,可能是抑制物存活率延长的重要原因之一。
The effect of transfusion on T lymphocyte function was investigeted in a C57BL/6J mouse model.Singal allogeneic blood transfusion of C57BL/6J mice was found to decrease delayed hy- persensitivity (DTH)and proliferative response of splenocytes to concanavalin A (ConA).Two transfusions was demonstrated not only to more significantly supress DTH and response to ConA but also to invent the suppressor to helper T cell ratio by increasing suppressor numbers.Syngene- ic transfusion did not alter T lymphocyte function.The immunosuppression seen following trans- fusions appeares to be related to H-2 major histocompatibility complex and the number of transfu- sion.
出处
《潍坊医学院学报》
1993年第4期265-267,共3页
Acta Academiae Medicinae Weifang
关键词
输血
免疫抑制
淋巴细胞
transfusion
T lymphocyte
immunosuppression
