摘要
A HPLC method for determination of three impurities in sulfamonomethoxine was established. A CLC-ODS column was used with the mobile phase of 0.05mol/L KH2PO4 solution- acetonitrile (86∶14) at the detection wavelength of 256nm. The calibration curves of three impurities were linear (r>0.999) in the concentration ranges of 3 - 240μg/ml, 3 - 120μg/ml and 3 - 60μg/ml, respectively. The average recoveries were 101.1%, 102.2% and 102.8%, respectively. The detection limit of three impurities was 100ng/ml.
A HPLC method for determination of three impurities in sulfamonomethoxine was established. A CLC-ODS column was used with the mobile phase of 0.05mol/L KH2PO4 solution- acetonitrile (86∶14) at the detection wavelength of 256nm. The calibration curves of three impurities were linear (r>0.999) in the concentration ranges of 3 - 240μg/ml, 3 - 120μg/ml and 3 - 60μg/ml, respectively. The average recoveries were 101.1%, 102.2% and 102.8%, respectively. The detection limit of three impurities was 100ng/ml.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2005年第2期102-103,共2页
Chinese Journal of Pharmaceuticals
