摘要
作者研究了维生紊A乙酸酯(RAc)和β—胡萝卜素对C57BL/6N小鼠Lewis肺癌(LLC)的治疗作用。实验设对照组、卡氮芥(BCNU)组、β—胡萝卜素组、BCNU+β—胡萝卜素组及RAc组。每组动物20只。RAc和β—胡萝卜素经饲料摄入。实验结果表明:RAc能抑制LLC生长(48.3％)、延长宿主寿命(18.8％);β—胡萝卜素的抗癌作用比等国际单位(200,000I U)的RAc弱,与BCNU联用时有协同抗癌作用。RAc组小鼠肝维生素A含量大幅度升高。不同处理组小鼠LLC肺转移率与对照组无明显差别。
Therapeutic effects of dietary retinyl acetate (RAc ) and *-carotene sup-plementation, on LLC in C57BL/6N male mice were investigated., Mice implanted (sc) with 10 5 viable LLC cells/mouse were divided into five groups (20 mice/group): Control, BCNU (30 mg/ kg bw, ip),*-Catotene (120 mg/kg in diet), BCNU +*-Carotene, and RAc (66.58 mg/kg in diet). We found that RAc inhibited LLC growth (48.3%) and prolonged host survival time (18.8%). The effect of *-carotene was weaker than that of RAc, at the equivalent dose (200,000IU) of .vitamin A. The combination of BCNU with *-carotene has been shown to have higher inhibition rate on the growth of LLC. Liver vitamin A level of RAc group increased greatly (to 3, 425.7 +++++++++ 358.2 IU/g liver). No significant difference has been found in LLC lung matastasis rates between the groups with various treratments.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1989年第1期25-28,共4页
Chinese Journal of Cancer
