摘要
对从苦参生药中制备的3种制剂——苦参总黄酮、苦参乙醇提取物和苦参总生物碱的体外抗贾第虫药物作用做了观察.在与贾第虫滋养体培养72h 后,它们的致死浓度分别为2.5、0.5和5mg/ml,即100%虫体死亡;当其浓度分别为0.5、0.25和2.5mg/ml 时,虫体生长受到抑制;浓度分别在0.05、0.05和0.5mg/ml 时,虫体生长不受影响。与甲硝哒唑相比,它们的用量虽较大,但均有杀灭虫体的作用。本实验的结果支持临床上应用苦参治疗贾第虫病。
Three preparations,alkaloid,ethanol extract and flavonoid,prepared from the Sophora feavecens Ait (Sophora angustifolia)were evaluated in vitro for antigiardia effect.The lethal concentrations of the 3 agents were 2.5mg/ml,0.5mg/ml and 5mg/ml respectively on the 72nd hour after cultivated with G.lamblia trophozoites.When their concentrations were 0.5 mg/ml,0.25mg/ml and 2.5mg/ml respectively,the growth of the trophozoites was inhi- bited.No antigiardia effect could be found as their concentrations were 0.05 mg/ml,0.05 mg/ml and 0.5mg/ml respectively.In comparison of the effects of the agents with that of mitronidazole,a similar antigiardia effect was observed.The present results support the clini- cal therapy for giardiasis by using the herb Sophora feavecens Ait.
关键词
贾第虫
苦参
总黄酮
乙醇提取物
Giardia lamblia
Sophora feaveeens Ait
flavonoid
ethanol extract
alkaloid
