摘要
目的 探讨1～10岁厌食症患儿和正常小儿血清瘦素与甲状腺激素、锌、铁含量、体重指数(BMI)的关系及其在厌食症发病过程中的作用。方法 用放射免疫方法检测54例厌食症患儿和46名正常小儿血清瘦素、甲状腺激素含量;同时用原子吸收法和亚铁嗪比色法测定血清锌、铁的含量,2组均测量身高和体重计算BMI。结果 厌食症组患儿血清瘦素、甲状腺激素、锌、铁含量显著低于正常小儿组水平(P<0.05和P<0.01);血清瘦素水平与血清锌、甲状腺激素含量呈正相关(Zn:r=0.46,P<0.01;T3:r=0.49,P<0.05;T4:r=0.56,P<0.05),与血清铁含量无相关性(Fe:r=0.14,P>0.05),与BMI无明显线性关系(男:r=0.12,P>0.05;女:r=0.26,P>0.05)。结论 瘦素、甲状腺激素和锌在厌食症发病机制中均发挥一定作用,共同影响厌食症患儿的食欲。
Objective To investigate the relationship between serum leptin concentration and levels of thyroid hormones, zinc, iron and body mass index(BMI) in 1-10 age apositia and healthy children. Methods Leptin and thyroid hormones were measured by RIA, zinc and iron by atomic absorption and ferro-zinc chromatometry in 54 apositia and 46 healthy children. Their body height and weight were measured for BMI. Results The concentration of leptin, thyroid hormones, zinc and iron in apositia children were lower than those in healthy children(P<0.05 and P< 0.01). Serum leptin levels were significantly correlated with thyroid hormones and zinc(Zn: r=0.46, P<0.01; T 3: r=0.49, P<0.05; T 4: r=0.56, P<0.05) and not correlated with iron and BMI(Fe: r=0.14, P> 0.05; BMI: r=0.12, P>0.05 in male and r=0.26, P> 0.05 in female). Conclusions Leptin, thyroid hormones and zinc play role in mechanism of apositia and effect appetite of apositia children.
出处
《检验医学》
CAS
北大核心
2005年第1期1-3,共3页
Laboratory Medicine
