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SDH基因与嗜铬细胞瘤 被引量:4

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摘要 编码线粒体琥珀酸脱氢酶B、D亚单位 (SDHB、SDHD)的基因突变可造成氧感受通路异常 ,参与肿瘤的血管形成 ,它们作为抑癌基因在头颈部家族性副神经节瘤的发病中起重要作用。其在家族性和散发性嗜铬细胞瘤中是否存在突变 ,目前结果还不一致。但SDHD和SDHB基因突变应作为嗜铬细胞瘤的基因检测的项目之一。
机构地区 中国医学科学院
出处 《国外医学(内分泌学分册)》 2005年第1期58-60,共3页 Foreign Medical Sciences(Section of Endocrinology)
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