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成人迟发自身免疫性糖尿病的基因背景 被引量:3

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摘要 成人迟发自身免疫性糖尿病 (LADA)是一多基因遗传疾病。人类白细胞抗原 (HLA)基因与LADA的发病、发病年龄、自身抗体有关。与主要组织相容性复合物Ⅰ类链相关的A基因 (MICA基因 )多态性和一些非HLA基因如神经分化因子 / β细胞E盒转录激活因子 2 (NeuroD/BETA2 )基因、肿瘤坏死因子 α启动子多态、细胞毒性T淋巴细胞相关抗原 4、CD38及其自身抗体也与LADA的发病有一定关系。
出处 《国外医学(内分泌学分册)》 2005年第1期53-55,共3页 Foreign Medical Sciences(Section of Endocrinology)
基金 国家自然科学基金资助项目 (3 970 0 0 69) 四川省科技厅重点基金资助项目 (G0 0 99)
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  • 2Vauhkonen I, Niskanen L, Knip M, et al. Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults. Diabetologia,2000,43:69-78.
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二级参考文献1

  • 1Donner H,J Clin Endoc Metab,1997年,82卷,143页

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