姜黄煎剂对银屑病皮损中CD45RO、VEGF和iNOS表达的影响被引量：3

Effects of Curcuma on Expression of CD45RO, VEGF and iNOS in Psoriatic Lesions

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摘要目的研究姜黄煎剂对寻常性银屑病的治疗效果,并探讨其可能的治疗机制。方法记录姜黄煎剂治疗前后皮损PASI评分,用免疫组化方法检测治疗前后皮损中CD45RO、VEGF和iNOS的表达。结果①姜黄煎剂治疗2月后PASI积分的下降有显著统计学意义(P<0.01)。②治疗后CD45RO阳性T细胞减少(P<0.05),CD45RO+T细胞数目与PASI积分正相关(r=0.899,P<0.05)。③治疗后VEGF和iNOS阳性表达较治疗前明显下降(分别为P<0.01,P<0.05)。二者染色评分与PASI无相关性(P>0.05)。结论姜黄对寻常性银屑病有较好的治疗效果,其治疗作用可能和皮损中CD45RO+记忆性T细胞减少有关。 Objective To evaluate the therapeutic effects of curcuma on psoriasis and to investigate possible therapeutic mechanism. Methods The severity of symptom of psoriasis was assessed by PASI score before and after curcuma treatment.The expression of VEGF , iNOS and CD45RO was studied by immunohistochemical technique. Results ①PASI scores of psoriasis patients decreased significantly after curcuma treatment(P<0.01).②The number of CD45RO positive T cells decreased significantly after curcuma treatment(P<0.05).There was positive correlation between the number of CD45RO+ T cells and PASI scores(r=0.899, P<0.05).③The expression of VEGF and iNOS decreased markedly after curcuma treatment(respectively P<0.01, P<0.05). There was no correlation between the level of VEGF and iNOS expression and PASI score (P>0.05). Conclusion Curcuma have satisfactory therapeutic effects on psoriasis vulgaris .The decrease of CD45RO+ T cells in lesional skin may be relevanted to the therapeutic mechanism of curcuma.

作者陈慧肖君刚张勇

机构地区青岛大学医学院附属医院皮肤科

出处《中国中西医结合皮肤性病学杂志》 CAS 2004年第4期198-201,共4页 Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

关键词 CD45RO 煎剂姜黄 PASI VEGF 治疗后治疗前后结论评分积分 psoriasis curcumin CD45RO vascular endothelial growth factors inducible nitric oxide synthase

分类号 R758.63 [医药卫生—皮肤病学与性病学] R282 [医药卫生—中药学]

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