摘要
目的探讨重酒石酸长春瑞滨联合5-氟尿嘧啶治疗胃癌的临床疗效。方法33例中晚期胃(贲门)癌患者均经胃镜、病理组织学诊断明确,重酒石酸长春瑞滨+5-氟尿嘧啶组17例(治疗组),丝裂霉素+5-氟尿嘧啶组16例(对照组),均完成1个疗程化疗,两组共配合相同辅助治疗。结果治疗组有效率为35.3%(6/17),对照组有效率为25.0%(4/16),两组差异无显著性(P>0.05)。两组不良反应相比较,骨髓抑制和浅静脉炎发生率差异无显著性(P>0.05),胃肠道反应差异有显著性(P<0.05)。结论重酒石酸长春瑞滨+5-氟尿嘧啶治疗胃癌疗效与丝裂霉素+5-氟尿嘧啶治疗胃癌疗效无显著性差异,治疗过程中患者胃肠道反应有明显差异,丝裂霉素+5-氟尿嘧啶治疗胃癌胃肠道反应较重,恶心、呕吐明显,患者不能耐受;重酒石酸长春瑞滨+5-氟尿嘧啶,患者胃肠道反应较轻,耐受性较好,临床可用于胃肠道肿瘤化疗。
To investigate clinical efficacy of chemotherapy combinated vinorelbine with 5-Fluorouracil in treatment of advanced Gastric carcinoma. 33 cases of advanced Gastric (cardia)carcinoma were divided randomly into two groups: Vinorelbine and 5-Fluorouracil group were 17 cases, Mitomycin and 5-Fluorouracil group were 16 cases, they all had been finished for one period of treatment,two groups had homological assistant treatment. The response rates of treat group was 35.3 %(6/17), The response rates of collate group was 25.0%(4/16). Toxicity of two groups was compared, marrow restrain and shallow phlebitis had no significant difference between treat group and collate group(P >0.05),gastrointestinal toxicity had significant difference between treat group and collate group (P <0.05). [Conclusion] The effect has no significant difference between Vinorelbineand 5-Fluorouracilin with Mitomycin and 5-Fluorouracil in treatment of advanced Gastric carcinoma, gastrointestinal toxicity has significant difference in treatment, gastrointestinal toxicity is serious in Mitomycin + 5-Fluorouracil, nausea and vomit are obvious,atients can not tolerate; gastrointestinal toxicity is well in vinorelbine + 5-Fluorouracilin, patients can tolerate. It may be chemotherapy combinated in advanced Gastric carcinoma.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2005年第1期89-91,共3页
China Journal of Modern Medicine
