摘要
血管紧张素转化酶抑制药(ACEI)和阿司匹林(Asp)广泛联合应用于治疗心血管疾病,但有关两药联合应用时的相互作用引起争论,使联合用药的安全性存在疑问,但也有研究反驳了Asp会削弱ACEI有益作用的论点,支持在ACEI治疗心血管疾病中应用Asp的安全性。本文综述了ACEI和Asp在高血压、急性心肌梗死、充血性心力衰竭应用中的相互作用,提示对两药的相互作用应予以特别关注。
Both aspirin and angiotensin converting enzyme(ACE)inhi bi tors are often used concomitantly in patients with cardiovascular disease.The s afety of the combination has been questioned. The potential antagonistic interac tions between ACE inhibitors and aspirin has become the focus of both increasing research and intense debate,with conflicting conclusions havin g been reported in the literature.We reviewed systematically available literatu re on the interactions between ACE inhibitors and aspirin in hyper- tension,acute myocardial infarction and congestive heart failure and found that further trials are needed to shed light on the effects and mechanism of interaction between these drugs.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2005年第1期14-17,共4页
Chinese Pharmacological Bulletin
