摘要
特异性环氧化酶-2(COX-2)抑制药为一组新的非甾体类抗炎药(NSAIDs),此类药能阻止前列腺素合成,但不阻止由COX-1激活的前列腺素类物质的合成。COX-2抑制药能迅速提供镇痛,对骨关节炎和类风湿性关节炎的抗炎镇痛效应相当于非特异性NSAIDs的标准剂量,而其胃肠道副作用较低,其他不良反应与非特异性NSAIDs相似。
Specific cyclooxygenase-2(COX-2) inhibitors constitute a new group of non-steroidal antiin-flammatory drugs (NSAIDs) which, at recommended doses, block prostaglandin production by cyclooxygenase-2, but not by cyclooxygenase-1. COX-2 inhibitors act rapidly in providing pain relief and their anti-inflammatory analgesic effect in osteoarthntis and rheumatoid arthritis is equivalent to standard doses of non-selective NSAIDS. COX-2 inhibitors show significantly lower incidences of gastrotoxicity than non-selective NASIDs. Other adverse effects, such as interference with antihypertensive agents and the potential to produce renal dysfunction in patients with compromised renal function by COX-2 inhibitors, seem similar to those of non- selective NASIDs.
出处
《实用疼痛学杂志》
2005年第1期42-49,共8页
Pain Clinic Journal
