摘要
目的 探讨肝管胆囊吻合术 (hepaticocholedochostomy,HC)和肝管空肠吻合术 (hepaticojejunostomy,HJ)两种胆道重建术的动物模型建立方法 ,并比较其近期疗效。方法 健康成年杂种犬 2 9只 ,随机分为对照组 (5只 )和不全梗阻模型组 (2 4只 )。不全梗阻 7周后随机分为 HC组 (n=12只 )和 HJ组 (n=12只 ) ,分别实施 HC和 HJ。观察其术中情况及术后 1个月疗效。 结果 不全梗阻后肝管直径明显扩张 ;HC组手术时间、术中出血量及术后 1个月体重下降均低于 HJ组 ,差异有统计学意义 (P<0 .0 5 ) ;HC和 HJ术后 1个月时 ,肝功能各项指标均恢复正常。 结论 在不全梗阻的基础上建立胆道重建动物模型是可行的 ;HC较 HJ术中损伤小 ,术后恢复好。
Objective To discuss the way of animal model building of hepaticocholedochostomy(HC) and hepaticojejunostomy(HJ) and to compare the short term effect. Metheds Twenty nine dogs were divided randomly into control group(?n?=5) and the experimental group (stenosis of left hepatic duct, ?n?=24). After 7 weeks of stenosis of left hepatic duct, 24 dogs in the experimental group were divided randomly into HC subgroup (?n?=12) and HJ subgroup (?n?=12) .The operation time and the blood loss during operation were recorded and the hepatic function was detected. Results The diameter of left hepatic duct was significantly expended after 7 week's stenosis. Hepaticocholedochostomy took shorter time and lost less blood than hepaticojejunostomy. The dogs in HC subgroup lost less weight than those in HJ subgroup. In HC and HJ subgroups, the mortality rates were 1/12 and 3/12; the infectious rates of incision were a(c)3/12 and 5/12 respectively. Serum levels of total bilirubin and transaminase increased significantly in the 7th week after stenosis of left hepatic duct compared with before stenosis of left hepatic duct. However, Serum levels of total bilirubin and transaminase restored to normal levels after 1 month of HC or HJ. Conclusion It is feasible to establish animal model of bile duct reconstruction on the basis of stricture of bile duct. The dogs undergoing hepaticocholedochostomy have less trauma, better results than the dogs undergoing hepaticojejunostomy. Both hepaticocholedochostomy and hepaticojejunostomy are able to relieve the obstruction of bile duct. ?3/4
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2005年第2期149-152,共4页
Chinese Journal of Reparative and Reconstructive Surgery
