摘要
采用IFA法检测了32例慢性活动性乙型肝炎外周血T细胞亚群CD_4/CD_8比值和免疫球蛋白IgG、IgA。结果表明,CD_4明显降低,CD_8明显升高,CD_4/CD_8比值显著下降;IgG、IgA明显升高;并发现CD_4/CD_8比值与IgG(γ=-0.485,P<0.01)及IgA(γ=-0.308,P<0.05)呈直线负相关;对其中6例患者进行了动态观察,结果提示,慢性活动性乙型肝炎的细胞免疫功能紊乱导致体液免疫功能异常亢进。
Peripheral T cell subsets were determined by IFA method in
32 patients with chronic active hepatitis-B,and the serum IgG,IgA were
detected at the same time。Comparing with the controls,the results showed
that CD_4 cells were markedly decreased(P<0.01),CD_8 cells increased(P
<0.01),CD_4/CD_8 ratio was decreased(P<0.01),IgG and IgA were
increased(P<0.01,P<0.05);there was a significant negative correlation
between CD_4/CD_8 ratio and IgG(r=-0.485,P<0.01),and IgA(r=-
0.308,P<0.05).6 cases were dynamiclly determined.The study indi-
cates that the imbalance of cellular immunity results in abnormality of hu-
moral immunity.
出处
《山东医科大学学报》
1993年第1期17-19,共3页
Acta Academiae Medicinae Shandong
关键词
乙型肝炎
T细胞
免疫球蛋白G
Hepatitis,chronic active
Hepatitis B
T lymphocytes
Antibody formation
IgA
IgG
Fluorescent antibody
