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CAP方案配合干扰素双途径化疗治疗卵巢上皮癌的临床观察 被引量:1

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摘要 目的 探讨全身静脉化疗加腹腔化疗双途径给药治疗卵巢上皮癌的疗效。方法 对 72例卵巢上皮癌患者均采用CAP方案化疗。A组 (38例 )环磷酰胺、阿霉素 (或吡喃阿霉素 )经静脉滴注 ,顺铂、干扰素经腹腔灌注 ;B组 (34例 )环磷酰胺、阿霉素 (或吡喃阿霉素 )及顺铂全部经静脉滴注。间隔 3~ 4周 ,共 6~ 8个疗程。结果 A组治疗总有效率 89.4 8% ,腹水得到有效控制 ;B组总有效率 6 7.6 5 %。两组比较有显著差异。两组 3年生存率分别为 4 7.37%、4 4 .12 % ,A组高于B组 ,但差异无统计学意义。结论 顺铂、干扰素腹腔灌注可减轻药物的副作用 ,提高治疗的总有效率 ,改善患者生存质量 ,但对提高 3年生存率的意义尚不肯定。
出处 《中国综合临床》 北大核心 2005年第1期81-83,共3页 Clinical Medicine of China
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参考文献14

  • 1连利娟.卵巢癌化疗的现况与趋向[J].中华妇产科杂志,1996,31(2):67-70. 被引量:39
  • 2姜正华,朱慕云,吕元文,俞婉珍,宗文九,胡觉文.干扰素γ与化疗药物协同抑制肺癌细胞系的生长[J].中国癌症杂志,2000,10(4):296-298. 被引量:4
  • 3肖成祖.IFN研究进展和技术[M].北京:人民军医出版社,1991.39,76.
  • 4魏熙胤,李凯,梁彦,牛瑞芳,李兰芳.干扰素抗肿瘤实验及临床治疗观察[J].中国肿瘤临床,2003,30(5):337-341. 被引量:4
  • 5曾学清,段功香,蒋湘莲,谭邦青.干扰素在抗肿瘤方面的应用[J].中国生化药物杂志,2003,24(4):215-216. 被引量:8
  • 6Alberts DS, Liu PY, Hannigan EV,et al. lntrapefitoneal cisplatin plus intravenous cyclophosphamide versus intravenous cisplatin plus intravenous cyclophosphamide for stage Ⅲ ovarian cancer [ J ]. N Engl J Med, 1996,335 ( 26 ) : 1950-1955.
  • 7Matsumoto Y, Deguchi M, Ishiko O, et al. Retrospective study of the prognostic factors of remission induction for single-agent chemotherapy with cisplatin in advanced epithelial ovarian cancer[J]. OncolRep,2000,7 (2) :311-313.
  • 8Lucas WE, Markman M, Horuell SB. Intrapefitoneal chemotherapy for advanced ovarian cancer[J]. Am J Obstet Gynecol, 1985,15(4) :474-478.
  • 9Petru E, Lahousen M ,Tamussino K, et al. Prognostic implications of residual tumour volume in stage Ⅲ ovarian cancer patients undergoing adjuvant cytotoxic chemotherapy [ J ]. Baillieres Clin Obstet Gynaecol, 1989,3 ( 1 ) : 109-117.
  • 10Reed E,Zerbe CS, Brawley OW,et al. Analysis of autopsy evaluations of ovarian cancer patients treated at the National Cancer Institute,1972-1988[J]. Am J Clin Oncel,2000,23(2) :107-116.

二级参考文献38

  • 1李凯 庹培昱 庞燕.干扰素实体瘤内注射后药物分布及瘤内免疫、病理状态观察[J].中国免疫学杂志,1999,15(1):48-48.
  • 2Jing H, Linj J, Tao J, et al. Suppression of human ribsomae protein L23A expression during cell growth inhibition by IFN-β[J]. Oncogene,1997,14(4) :473-476.
  • 3Saily M, Koistenen P, Soppi E, et al. Effect of interferon-alpha on immunoglobulin production by peripheral blood mononuclear cells in multiple milkman[J]. Eur J Haematol, 1996,57(2) : 171-173.
  • 4Strander H, Bauer HC, Brosjo O, et al. Long-term adjuvant interferon treatment of human osteosarcoma : A pilot study[ J ]. Actaoncol, 1995,34 : 877-880.
  • 5Chu E, Zinn S, Boarman D, et al. Interaction of γ-interferon and 5-fluorouracil in the H630 human colon carcinoma cell line[ J ]. Cancer Res, 1990,50 ; 5834-5840.
  • 6肖成祖.IFN研究进展和技术[M].北京:人民军医出版社,1991.39,76.
  • 7MossmanT.Rapidclolrimetricassayforcellulargrowthandsurvial:applicationtoproliferationandcytotoxicityassays[J].JImmunolMethods,1983,65(1):55-63.
  • 8BeruhardH,Jager-ArandE,BeruhardG,etal.Treatmentofadvancedpancreaticcancerwith5-fluorouracil,follicacidandinterferonalpha-2a:resultsofaphaseⅡtrial[J].BrJCancer,1995,71(2):102-108.
  • 9TemeckBK,LiebmanJE,TheodossionC,etal.PhaseⅡtrialof5-fluorouracil,leucovorininterferon-a-2aandcisplatinasneoadjuvantchemotherapyforlocallyadvancedesophagerlcaricinoma.Cancer,1996,77(10):2432-2240.
  • 10KhuriFR,FossellaFV,LeeJS,etal.PhaseⅡtrialofrecombinantIFN-alpha-2awithetoposide/cisplatininductionandinterferon/megestrolacetatemaintenanceinextensivesmall-celllungcancer[J].JInterferonCytokineRes,1998,18(4):241-245.

共引文献52

同被引文献8

  • 1Hamilton CA,Berek JS.Intraperitoneal chemotherapy for ovariancancer[J].Curr Opin Oncol,2006,18(5):507-515.
  • 2Bristom RE,Tomacruz RS,Armstrong DK,et al.Survival effectof cytoreductive surgery for advanced ovarian carcinoma duringthe platinum:a meapetra analysis[J].Clinoncol,2002,20(5):1248-1259.
  • 3Gadducci A,Cosio S,Conte PF,et al.Consolidation and mai-ntenance treatments for patients with advanced epithelial ovariancancer in complete response after first line chemotherapy:areview of the literature[J].Crit Rev Oncol Hematol,2005,55(2):153-166.
  • 4周际昌.实用肿瘤内科学[M].第2版.北京:人民卫生出版社,2005:29-30.
  • 5宋坤,孔北华.卵巢癌腹腔化疗的有关问题[J].现代妇产科进展,2010,19(10):721-724. 被引量:10
  • 6方修平.晚期胃肠道肿瘤术后双途径化疗临床疗效观察[J].咸宁学院学报(医学版),2010,24(6):494-495. 被引量:4
  • 7蒋瑛,李惠新.卵巢癌化疗进展[J].中国现代医药杂志,2011,13(6):127-128. 被引量:5
  • 8林芳,彭一,杜驰,蒋吉飞,蔡明伟.晚期卵巢癌新辅助化疗的疗效分析[J].现代预防医学,2011,38(13):2637-2639. 被引量:16

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