摘要
本文对大鼠颈动脉体在低氧环境的变化进行了体视学研究。`光镜和电镜下分别测试了颈动脉体Ⅰ型细胞及线粒体和电子致密核心小泡(EDCV)的各参数。分析表明,在海拔3416米的自然低氧下饲养7天,Ⅰ型细胞比例减少,胞质增多,微血管增加,线粒体增生,EDCV增多,反映了细胞的代偿化变化。高原饲养30天,Ⅰ型细胞比例进一步下降,微血管明显扩张,线粒体膨胀,嵴破坏,EDCV减少,大小分布不均匀,反映了失代偿引起的损伤性变化。返回到397米7天,光镜结构有不完全恢复,而电镜出现了极明显的变化。
The changes happened in the carotid bodies of rats under the condition of high--al- titude hypoxia were examined using stereological method. Under LM and EM, the pa- rameters of carotid body type--I cells, their nuclears, the mitochondria and EDCV were measured individually. The analysis of the carotid bodies of Wistar rats born and reared at the altitude of 397 meters showed that: After 7 days at the altitude of 3416 meters, the volume density of type--I cells decreased, while their cytoplasm increased. Micro--vessels increased re- markably. The volume density and numerical density of the mitochondria and EDCV also increased. This indicated an augmenting status. After the rats living at high altitued for 30 days, the volume density of the type--I cells in the organ further reduced, and the mi- crovessels expanded. The mitochondria swelled with their cristae destroyed, and the ED- CV reduced, with an unbalanced distribution of size and location. It reflected the injury of the tissue and the attenuation of the function. Returing to 397 meters for 7 days after being raised at 3416 meters for 30 days, it is showed that the recovery from the injury at LM level was incomplete but there is an overecompensation at EM level.
出处
《青海医学院学报》
CAS
1993年第3期145-152,共8页
Journal of Qinghai Medical College
