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老年糖耐量低减者脂代谢异常及肌酸激酶同工酶变化的临床意义

The clinical significance of abnormal lipid metabolism and creatine kinase in elderly patients with impaired glucose tolerance
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摘要 目的探讨老年糖耐量低减(IGT)患者的脂代谢异常及肌酸激酶同工酶(CK-MB)变化的原因。方法分别测定IGT组(65例)和对照组(118例)的血液CK-MB活性和空腹血糖、胰岛素(INS)、胆固醇(CH)、甘油三脂(TG)、高密度脂蛋白-C(HDL-C)、低密度脂蛋白(LDL)水平。结果与对照组比较熏IGT组CK-MB活性明显升高穴P<0.01雪熏CH、TG、LDL、INS水平也明显升高穴P<0.05雪熏而HDL-C水平明显下降穴P<0.05雪。结论老年IGT患者可能因继发性INS增高而造成脂代谢紊乱及轻度心肌损害,在糖尿病前期IGT阶段即应重视对冠心病的预防。 Objective To investigate the abnormal lipid metabolism and CK-MB changes in elderly patients with impaired glucose tolerance ,IGT,. Methods The patients were divided into the study group ,65 cases with IGT, and the control group ,118 cases without IGT,, whose fasting blood sugar, fasting blood insulin, and Chol, TG, HDL, LDL, INS in blood were detected. Results The significant difference in CK-MB levels was found between the two groups ,P<0.01,, also in CH, TG, LDL, INS ,P<0.05,. Conclusion In IGT patients, metabolic disturbance of lipid and myocardial damage may result from secondary rise of insulin level.
作者 尹来 万长春
机构地区 金湖县人民医院
出处 《浙江医学》 CAS 2004年第12期891-892,共2页 Zhejiang Medical Journal
关键词 IGT 老年 肌酸激酶同工酶 脂代谢异常 糖耐量低减 CK—MB HDL—C 阶段 水平 目的 Impaired glucose tolerance Creatine kinase Abnormal blood-lipid
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  • 1耿纪录,陆菊明,潘长玉,刘艳芳,李颂,张锦明,陆小平.新诊断的NIDDM和IGT患者的早期肾功能改变[J].中国糖尿病杂志,1994,2(2):65-68. 被引量:30
  • 2Haffner SM, Miettinen H, Stern MP. The homeostasis model in the San Antonio heart study. Diabetes Care, 1997,20:1087-1092.
  • 3Phillips DI, Clark PM, Hales CN, et al. Understanding oral glucose tolerance: comparison of glucose of insulin resistance and secretion. Diabet Med , 1994,11:286-292.
  • 4Defronzo RA, Ferrannini E, Simensen DC. Fasting hyperglycemia in non-insulin-dependent diabetes mellitus, contributions of excessive hepatic glucose production and impaired tissue glucose uptake. Metabolism, 1989,38:387-395.
  • 5Pimenta W, Korytkowski M, Mitrakou A, et al. Pancreatic β-cell dysfuction as the primary genetic lesion in NIDDM: evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative. JAMA, 1995,273:1855-1861.
  • 6Melchionda N, Forlani G, Marchesini G, et al. WHO and ADA criteria for the diagnosis of diabetes mellitus in relation to body mass index. Insulin sensitivity and secretion in resulting subcategories of glucose tolerance. Int J Obes Relat Metab Disord, 200
  • 7Li CL, Tsai ST, Chou P. Comparison of metabolic risk profiles between subjects with fasting and 2-hour plasma glucose impairment: The Kinmen Study. J Clin Epidemiol, 2002,55:19-24.
  • 8Weyer C, Bogardus C, Pratley RE. Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance. Diabetes, 1999,48:2197-2203.
  • 9Davies MJ, Raymond NT, Day JH, et al. Impaired glucose tolerance and fasting hyperglycaemia have different characteristics. Diabet Med, 2000,17:433-440.
  • 10Unger RH, Faster DW, Diabetes mellitus. In: Wilson JD, et al (eds). Williams textbook of endocrinology. 9th ed. Philadelphia: Saunders, 2001,1008-1009.

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