摘要
目的 :比较丙戊酸钠与碳酸锂治疗躁狂发作的疗效和不良反应。 方法 :对 80例躁狂发作患者随机均分为丙戊酸钠组和碳酸锂组 ,在治疗前 ,治疗 2、4、8周末分别用Bech Rafaelsen躁狂量表(BRMS)和临床疗效总评量表 (CGI)及副反应量表 (TESS)评定疗效和不良反应。 结果 :丙戊酸钠组治疗 2周后BRMS总分 ,及各因子分比治疗前明显降低 ,且显著低于碳酸锂组 ,两组治疗 8周BRMS总分各因子分均显著低于治疗前 ,差异显著。治疗 2、4、8周末TESS评分 ,丙戊酸钠组显著低于碳酸锂组 ,差异有显著性。 结论 :丙戊酸钠治疗躁狂发作疗效好 ,起效快 。
Objective:To observe the efficacy and side effects of sodium valproate and lithium carbonate in the treatment of manic episode. Method:Eighty patients with manic episode were divided into study group (sodium valproate) and control group (lithium carbonate) randomly.Efficacy and side effects were assessed with BRMS,CGI and TESS respectively before treatment and after treatment for 2,4,8 weeks. Results:After two weeks treatment, the total score of BRMS and the score of each factor were significantly lower than that before treatment in study group,and the scores of treatment factors and TESS was significantly lower in study group than in control group. Conclusion:Sodium valproate is more effective and well tolerated in the treatment of manic episode.
出处
《临床精神医学杂志》
2004年第6期346-347,共2页
Journal of Clinical Psychiatry
关键词
躁狂发作
丙戊酸钠
碳酸锂
Manic episode
Sodium valproate
Lithium carbonate.
