摘要
对110例甲型肝炎(甲肝)患者外周血淋巴细胞亚群检测。发现甲肝患者与正常人相比外周血 CD_3^+细胞、CD_4^+细胞明显减少,CD_(?)^+细胞明显增多。CD_4^+/CD_8^+比值显著下降,且后者与肝功能损害程度及病程有关.资料还显示,在部分乙型肝炎病毒感染患者重叠甲肝病毒感染而致肝病发作时,外周血淋巴细胞亚群的变化可能与甲肝病毒有关.研究结果提示细胞免疫在甲肝的发病机理中起一定作用.
By the determination of the subgroup of the lymphocytes in the peripheral blood of 110 patients with hepatitis A,it is found out that the patients with hepatitis A had a significantly decreased number of CD_3^+ and CD_4^+ cells,a remarkably decreased number of CD_8^+ cells and a significantly dropped ratio of CD_4^+ to CD_8^+ in their peripheral blood,compared with normal individuals.It is also found out that the decreased ratio of CD_4^+ to CD_8^+ was related to the degree of the damaged liver function and the course of the disease.The data gathered in the study have also shown that the change in the subgroup of the lymphocytes in the peripheral blood may probably associated with hepatitis A viruses when the episode of the disease was caused by the superimposition of hepatitis A upon hepatitis B among some of the patients with hepatitis B.The research results have suggested that cellular immunity plays a certain role in the pathogenesis of hepatitis A.
出处
《南通医学院学报》
1993年第2期157-159,共3页
ACTA Academiae Medicinae Nantong
关键词
甲型肝炎
淋巴细胞亚群
细胞免疫
Hepatilis A
Subgroup of the lymphocytes in the peripheral blood
Cellular immunity
