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应用GM-CSF治疗恶性肿瘤化疗后白细胞减少的临床研究 被引量:1

The Uses of Granulocyte-Macrophage Colony-Stimulating Factor(GM-CSF) in Leucocytopenia After Chemotherapy in Patients with Malignant Tumor
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摘要 本文研究总结了北医联合生物工程公司研制的GM-CSF,应用于恶性肿瘤化疗引起的白细胞减少12例,其白细胞减少时间较对照组缩短5天。对合并感染的病人有较明显的抗感染作用,降低了抗生素的作用时间。临床应用常规剂量未发生明显副作用。是肿瘤根治性化疗的抢救、保驾药品。 The present study was designed to confirm the use of GM-CSF, made by the Beijing United Biological Engineering Company, in leucocytopenia after chemotherapy in 12 patients with malignant tumor. In patients with malignant tumor the interval leucocytopenia needed shortened 5 days compared with that in control subjects. At the same time GM-CSF could be resistant to infection significantly, especially in patients with complicated infection, and the antibiotic applying time decreased. In addition, clinical experence had shown that there was no obvious side-effects in general dosage. Thus, these findings indicate that GM-CSF is a kind of essential drug in radical chemotherapy in patients with tumor.
出处 《中国肿瘤生物治疗杂志》 CAS CSCD 1995年第3期197-200,共4页 Chinese Journal of Cancer Biotherapy
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  • 1窦焕福,韩祥,王良绪,王丽.粒细胞-巨噬细胞集落刺激因子治疗重型再生障碍性贫血2例[J].北京医学,1995,17(1):50-50. 被引量:2
  • 2Reynoso EE, Calderon E, Miranda E, et al. GM- CSF mouthwashes to attenuate severe mucositis after high dose chemotherapy and allogeneic bone marrow transplantation (BMT) or antologous peripheral blood stem cell transplantation (APBSCT). Annals Oncol , 199
  • 3Chi KH, Chen CH, Chan WK, et al. Effect of granulocyte macrophage colony stimulating factor on oral mucositis in head and neck cancer patients after cisplatin, fiuoruracil and leucovorin chemotherapy. J Clin Oncol, 1995; 13(10) :2620
  • 4Brandt SJ, Peters WP, Atwater SK, et al. Effect of recombinant human granulocyte-macrophage colony-stimulating factor on hematopoietic reconstitution after high-dose chemotherapy and autologous bone marrow transplantation. N - Engl - J -Med, 1988;318(14)
  • 5Troussard X, Macro M , Vie B , et al. Human recombinant granulocyte - macrophage colony stimulating factor (hrGM - CSF) improves double hemibody irradiation (DHBI) tolerance in patients with stage Ⅲ multiple myeloma: a pilot study . Br J Haematal,1995;89
  • 6王琳辉 鞠佃文 弭静.p16和GM—CSF联合的研究[J].中国肿瘤生物治疗杂志,1999,6(3):203-203.
  • 7王建设 朱启容 张婷.A pilot study on the combined therapy of granulocyte macrophage stimulating factor and hepatitis B vaccine on chronic hepatitis B viru carrier children[J].Chinese Medical Journal(中华医学杂志:英文版),2002,115(12):1824-1824.
  • 8王利军 厉健 邢林山.局部应用巨噬粒细胞集落刺激因子治性小腿溃疡[J].国外医学:内分泌学分册,2000,20(5):276-276.
  • 9马建新 张睢扬.外源性粒细胞—巨噬细胞集落刺激因子治疗肺泡蛋白沉积症[J].国外医学:内科学分册,2002,29(1):44-44.
  • 10单学健,王东林,刘宝江,徐富,王玉霞.小剂量GM-CSF对化疗后白细胞减少的治疗作用[J].中国肿瘤生物治疗杂志,1997,4(4):328-328. 被引量:1

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