摘要
采用微生物法和高效液相色谱法测定血与尿中培氟沙星浓度,研究8名健康志愿者随机交叉单次口服培氟沙星(甲磺酸培氟沙星)片剂和溶液剂各400mg后的药物动力学特征及相对生物利用度。结果表明:单次口服片剂和溶液剂后药时曲线符合口服开放性二室模型。片剂与水溶液相比,吸收完全,相对生物利用度为99.26±16.55%(微生物法)和98.86±12.56%(HPLC)。主要药动学参数除达峰时间溶液剂明显快(P<O.05)外,均无显著差异。
The pharmacokinetics and relative bioavailability single dose of 400 mg oral
Pefloxacin (Pefloxacin sulphonate) tablet or suspension were in vestigated using a random-
ized crossover study in 8 healthy sujests. The concentrations of pefloxacin in serum and urine
were detemined by microbiologic method and high performance liquid chromatographic
method. It was concluded that the drug time curves of single dose oral tabet and suspension
were fit for a two campartment open model. The absorption of tablet was fuller than suspen-
sion, the relative bioavaiiability was 99. 26±16. 55% (microbiologic method ), 98. 86±
12. 56% (HPLC method) respectively. Except the faster peak time of suspension (P<
0. 05), there were no significant differemces in the main pharmacokinetic parameters.
关键词
培氟沙星
生物利用度
片剂
pefloxacin
penfloxacin sulponate
pharmucokinetic
bioavailability
HPL C
