摘要
本研究采用大剂量去甲肾上腺素(NE)短时间静滴的方法,建立兔心肌损害模型,光镜下观察心肌病理形态改变,监测心肌酶谱、血cAMP/cGMP等代谢指标的变化,以及α、β受体阻滞剂对NE心肌损害的影响,探讨NE心肌损害的发病机制。
Large dose of norepinephrine(NE)given by rapid intravenous infusion was used to in- duce myocardial injury in New Zealand rabbits.Pathological changes of myocardium,myocardial en- zyme patterns,blood cAMP/cGMP were recorded.The influence of α-antagonist(Regitine)and β-an- tagonist(propranolol)on NE-induced myocardial injury was also investigated with respect to the mech- anism of NE-injury.
基金
国家自然科学基金
