摘要
AIM: To study morphologic and biomechanical changes of oesophagus in diabetes rats.METHODS: Diabetes was induced by a single injection of streptozotocin (STZ). The type of diabetes mellitus induced by parenteral STZ administration in rats was insulin-dependent (type I). The samples were excised and studied in vitro using a self-developed biomaterial test machine.RESULTS: The body mass was decreased after 4 d with STZ treatment. The length of esophagus shortened after 4, 7,14 d. The opening angle increased after 14 d. The shear,longitudinal and circumferential stiffness were obviously raised after 28 d of STZ treatment.CONCLUSION: The changes of passive biomechanical properties reflect intra-structural alteration of tissue to a certain extent. This alteration will lead to some dysfunction of movement. For example, tension of esophageal wall will change due to some obstructive disease.
AIM:To study morphologic and biomechanical changes of oesophagus in diabetes rats. METHODS:Diabetes was induced by a single injection of streptozotocin(STZ).The type of diabetes mellitus induced by parenteral STZ administration in rats was insulin-dependent(type I).The samples were excised and studied in vitro using a self-developed biomaterial test machine. RESULTS:The body mass was decreased after 4 d with STZ treatment.The length of esophagus shortened after 4,7, 14 d.The opening angle increased after 14 d.The shear, longitudinal and circumferential stiffness were obviously raised after 28 d of STZ treatment. CONCLUSION:The changes of passive biomechanical properties reflect intra-structural alteration of tissue to a certain extent.This alteration will lead to some dysfunction of movement.For example,tension of esophageal wall will change due to some obstructive disease.
