摘要
目的研究 3β 羟基 雄甾 5 ,15 二烯 17 酮的合成方法。 方法以去氢表雄酮为原料 ,经过溴代、缩酮化、脱溴化氢、脱缩酮保护基反应得到目标产物 ,总产率 32 1%。结果与结论合成路线简便易行 ,适于大规模制备。
Aim To find a synthetic method of the target compound.Methods The target compound was synthesized from dihydroepiandrosterone via bromination,forming ethylene glycol ketal for protection,dehydrobromination,removing ketal blocking group with acid in a total yield of 32.1%.Results and conclusion A easy synthetic route suitable for large scale manufacture was found.
出处
《中国药物化学杂志》
CAS
CSCD
2004年第6期360-362,共3页
Chinese Journal of Medicinal Chemistry
