摘要
目的 :评价针刺合并帕罗西汀治疗抑郁症的临床疗效及安全性。方法 :对符合CCMD - 3抑郁症诊断标准的 5 7例抑郁症患者进行针刺合并帕罗西汀 (10mg d)和单纯帕罗西汀 (2 0mg d)治疗的对照研究 ,其中针刺合并帕罗西汀组 (针药组 ) 2 9例 ,帕罗西洒组 2 8例 ,共治疗 6周。采用汉密尔顿抑郁量表HAMD ,汉密尔顿焦虑量表HAMA ,临床总体评定量表CGI评定临床疗效 ,副反应量表TESS评定不良反应。结果 :经 6周治疗后 ,针药组总有效率 86 .2 1% ,显效率 6 2 .0 6 % ;帕罗西汀组分别为 82 .14 %、5 7.14 % ,两组比较无显著性差异 (P >0 .0 5 )。针药组治疗第 1周就起效。两组的HAMD、HAMA评分治疗前后相比较有显著性差异 (P <0 .0 1) ,两组之间比较无差异 (P <0 .0 5 )。针药组的不良反应相对于帕罗西汀组少而轻。结论 :针刺合并帕罗西汀治疗抑郁症疗效好 ,起效快 ,不良反应少而轻 ,适合临床应用。
The aim of this study was to determine the efficacy and safety of using acupuncture combined with paroxetine treating depressive patients.Methods: A controlled study was carried out between 57 patients who met the CCCMD-3 criteria of major depression and depressed episode.The 29 of total patients were treated with acupuncture combined with paroxetine (10mg/d) and others were treated with simple paroxetine (20mg/d) for 6 weeks.The efficacy were assessd by Hamilton Depression Rating Scale (HAMD),Hamilton Anxiety Scale (HAMA),Clinical Global Impression (CGI) and the safety was assessed by Treatment Emergent Symtom Scale (TESS).Results:After 6 weeks treatment,the improvement rate and significant improvement rate of acupuncture plus paroxetine group and paroxetine group were 86.21% and 62.06%;82.14% and 57.14%,respectively ( P >0.05).The efficacy strated after 7 days treatment in acupuncture plus paroxetine group.The scores of HAMD and HAMA in two groups were statistical difference before and after treatment ( P <0.01).There was no difference between two groups ( P >0.05).There were lower side effects in acupuncture plus paroxetine group than that in paroxetine group.Conclusion:Acupuncture plus antidepressant is an effective method which is suitable for clinical use.
出处
《针灸临床杂志》
2004年第12期17-19,共3页
Journal of Clinical Acupuncture and Moxibustion
关键词
抑郁症
针刺
抗抑郁药/帕罗西汀
临床观察
Depression
Acupuncture Therapy
Antidepressant/Paroxetine
Clinical Study
