摘要
以低度交联的单分散三聚氰胺甲醛(MF)微球作为胶体模板,采用逐层静电自组装技术,交替组装正负聚电解质,得到具有核壳结构的复合微球,然后利用盐酸溶液分解掉模板MF,从而形成均匀的空腔胶囊;并以盐酸阿霉素为例,对空腔胶囊的载药量及缓释性进行了初步研究. 结果显示,胶囊载药量可达27.07 mg/mL,胶囊对药物具有显著的缓释作用,释放半衰期t1/2=17.5 h.
Uniform hollow capsules were produced by the layer-by-layer electrostatic self-assembly technique. The core-shell microspheres were prepared by alternately depositing negative and positive polyelectrolytes onto theweakly-crosslinked MF microspheres which were used as solid templates, then the templates were decomposed by 0.1 mol/L hydrochloric acid to get hollow capsules. The loaded drug amount and controlled release from thecapsules were tested using Dexorubicin hydrochloride as the model medicine. The result shows that the loaded drug amount in the capsules is 27.07 mg/mg and capsules can slow down the release of Dexorubicin remarkably.
出处
《过程工程学报》
EI
CAS
CSCD
北大核心
2004年第6期513-518,共6页
The Chinese Journal of Process Engineering
基金
国家自然科学基金资助项目(编号:20276019)
国家863计划资助项目(编号:2002AA302208)
上海市纳米专项基金资助项目(编号:0243nm069)
关键词
逐层自组装
核壳式微球
空腔胶囊
载药
layer-by-layer self-assembly
core-shell microsphere
hollow capsule
drug load
