摘要
Corticosteroids are widely used for the treatment of chronic obstructive pulmonary disease COPD), but its effect is still controver- ( siallydiscussed.In order to explorethe mechanism of this therapy, some studies examine the cytokines-the markers of neutrophilic airwayinflammation of COPD aftertreatment withoral orinhaledcorticosteroids.Theyget some differentconclusions respectivelyonthelevel ofinterleukin-8(IL-8)andthecount of inflammatory cells and cellularity in the induced sputum or Bronchoalveolar lavage fluid(BALF). Furthermore, we still can’t explain the phenomenon that corticosteroids can elongation survival time of neutrophil.An oxidant/antioxidant imbalanceis thought to occur in patients withCOPD. Someone think corticosteroids have no effect on the oxidative stress of COPD and others disagree with this finding. For the purpose of evaluating the efficacy of cortico- steroids in thetreatment of COPD,some large RandomizedControlled, Multicenter, Clinical Trial have been completed in recent years.Most of these trials agreedthat long-term useofglucocorticoids couldimprove respiratory symptomsanddecreased the incidence rateof acute exacerbations ofCOPD.Several large trail proved that long-term use of inhaledglucocorticoids maybe of clinic benefit in acute COPDexacerbation,but it did not affect the long-term pro- gressive decline of forced expiratory volume in1 second FEV1). Special attention should be paid to smoking patients and elderly patients with COPDwho ( may be ignored by previous trials because of lack of respiratory symptoms or those who can’tolerate the examination of pulmonary function. t [
Corticosteroids are widely used for the treatment of chronic obstructive pulmonary disease COPD), but its effect is still controver- ( siallydiscussed.In order to explorethe mechanism of this therapy, some studies examine the cytokines-the markers of neutrophilic airwayinflammation of COPD aftertreatment withoral orinhaledcorticosteroids.Theyget some differentconclusions respectivelyonthelevel ofinterleukin-8(IL-8)andthecount of inflammatory cells and cellularity in the induced sputum or Bronchoalveolar lavage fluid(BALF). Furthermore, we still can’t explain the phenomenon that corticosteroids can elongation survival time of neutrophil.An oxidant/antioxidant imbalanceis thought to occur in patients withCOPD. Someone think corticosteroids have no effect on the oxidative stress of COPD and others disagree with this finding. For the purpose of evaluating the efficacy of cortico- steroids in thetreatment of COPD,some large RandomizedControlled, Multicenter, Clinical Trial have been completed in recent years.Most of these trials agreedthat long-term useofglucocorticoids couldimprove respiratory symptomsanddecreased the incidence rateof acute exacerbations ofCOPD.Several large trail proved that long-term use of inhaledglucocorticoids maybe of clinic benefit in acute COPDexacerbation,but it did not affect the long-term pro- gressive decline of forced expiratory volume in1 second FEV1). Special attention should be paid to smoking patients and elderly patients with COPDwho ( may be ignored by previous trials because of lack of respiratory symptoms or those who can’tolerate the examination of pulmonary function. t [
出处
《中国处方药》
2004年第12期30-33,共4页
Journal of China Prescription Drug
