摘要
目的 目前氟马西尼应用于肝性脑病的临床疗效存在很大争议 ,故设计此项分析 ,以得到一个定性且定量的结果。方法 将在MEDLINE和CNKI及手工检索 1983～ 2 0 0 3年发表的有关氟马西尼治疗肝硬化患者肝性脑病的随机对照临床试验资料。根据入选标准 ,有 7项临床试验纳入本研究 ,SPSS 11.5软件进行分析。结果 临床症状改善和脑电图改善的合并优势比 (OR值 )分别为 6 .5 7(4 .30～ 10 .0 4 ) ,6 .10 (4 .0 6～ 9.16 )。结论 氟马西尼治疗肝硬化合并急性肝性脑病的患者是有效的 。
Objective To obtain qualitative and quantitative results about Flumazenil in the testament of hepatic encephalopathy (HE) by using a Meta-analysis to give clinical therapy a reference.Methods MEDLINE, CNKI and a manual search were combined to obtain the RCTs literature (1983～2003) of Flumazenil used in HE treatment. Finally, 7 studies were accepted interventions, results etc, of the included studies respectively. Data were analysis by softwere SPSS 11.5.Results The pooled OR of clinical improvement and EEG improvement are 6.57 ( 4.30～ 10.04) , 6.10 ( 4.06～ 9.16).Conclusion Flumazenil is effective in the treatment of acute hepatic encephalopathy in patients with cirrhosis, Clinical an according to the inclusion criteria. 2 authors drew details about trial design, characters of participants, the EEG improvements are significant in patients receiving Fumazenil compared to patients treated with placebo.
出处
《华中医学杂志》
CAS
2004年第6期395-396,共2页
Central China Medical Journal
