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组蛋白乙酰化/去乙酰化与白血病的研究进展 被引量：19

Research Progress on Histone Acetylation/ Deacetylation and Leukemia
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摘要 组蛋白乙酰化/去乙酰化与基因调控密切相关。组蛋白乙酰化水平的异常在白血病的发展、增殖和分化中起着很重要的作用。随着对组蛋白乙酰化的深入研究,组蛋白去乙酰化酶抑制剂在白血病中的作用机制越来越受到人们的关注。 Histone acetylation/deacetylation is closely related to the regulation of gene. The level of histone acetylation plays an important role in progression, proliferation and differentiation of leukemia. With intensive study, the mechanism of histone deacetylase inhibitors in leukemia has been paid more and more attention.
作者 赵洁 苏琦
机构地区 南华大学肿瘤研究所
出处 《肿瘤学杂志》 CAS 2004年第6期436-439,共4页 Journal of Chinese Oncology
基金 湖南省教育厅科研基金项目(03C415)
关键词 组蛋白乙酰化/去乙酰化 组蛋白去乙酰化酶抑制剂 白血病 histone acetylation/deacetylation histone deacetylase inhibitor leukemia
分类号 R733.7 [医药卫生—肿瘤]
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参考文献26

  • 1[1]Chambers AE, Banerjee S, Chaplin T, et al. Histone acetylation-mediated regulation of genes in leukaemic cells [J].Eur J Cancer, 2003, 39(8): 1165-1175.
  • 2[2]Jay L'Grisolano, Julie O'Neal, Jennifer Cain, et al. An activated receptor tyrosine kinase, TEL/PDGFβR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice[J]. Medical Sciences, 2003,100(16):9506-9511.
  • 3[3]Hong J, Ishihara K, Yamaki K, et al. Apicidin,a histone deacetylase inhibitor, induces differentiation of HL-60 cells[J].Cancer Lett, 2003, 189(2):197-206.
  • 4[4]Lorincz MC, Schubeler D, Groudine M. Methylation-mediated proviral silencing is associated with MeCP2 recruitment and localized histone H3 deacetylation[J]. Mol Cell Biol, 2001, 21(23):7913-7922.
  • 5[5]Lea MA, Randolph VM, Patel M. Increased acetylation of histion induced by dially1 disulfide and structurally related molecules[J]. Int J Oncol,1999,15(2):347-352.
  • 6[6]Puccetti E, Obradovic D, Beissert T, et al. AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor[J].Cancer Res, 2002, 62(23):7050-7058.
  • 7[7]Ferrara FF, Fazi F, Bianchini A, et al. Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia[J]. Cancer Res, 2001,61(1):2-7.
  • 8[8]Lea MA, Rasheed M, Randolph VM, et al. Induction of histone acetylation and inhibition of growth of mouse erythroleukemia cells by S-allylmercaptocysteine [J]. Nutr Cancer, 2002, 43(1):90-102.
  • 9[9]Wittich S, Scherf H, Xie C, et al. Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells[J]. J Med Chem, 2002, 45(15):3296-3309.
  • 10[10]Kosugi H, Ito M, YamamotoY, et al. In vivo effects of a histone deacetylase inhibitor, FK228, on human acute promyelocytic leukemia in NOD / Shi-scid/scid mice [J].Jpn J Cancer Res,2001,92(5):529-536.

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肿瘤学杂志
2004年 第6期

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