摘要
目的 评价FDG PET对孤立性肺结节的临床诊断价值。方法 检索Cochrane图书馆、PubMed、OVID数据库 ,对纳入文献评估后 ,进行Meta分析 ,绘制SROC曲线 ,计算曲线下面积。最后进行敏感性分析。结果 Meta分析汇总的敏感性、特异性、阳性预测值、阴性预测值分别为 93 %、78%、90 %、85 % ,SROC曲线下面积为 93 .19%。与病理诊断的结果符合率达 90 .2 1%。结论 FDG PET是一种敏感性较高的诊断孤立性肺结节的非侵入性检查方法 ,但是特异性较低是其缺点。
Objective To estimate the diagnostic accuracy of FDG-PET for malignant solitary pulmonary nodules (SPN) by using a meta-analysis with the gold standard of pathological results. Methods Search in the studies in English published between January 1990 and February 2004 in PubMed, Ovid and Cochrane library. Criteria for inclusion and exclusion were according to the criteria of diagnostic research published by Cochrane center. Characteristics of the included studies were evaluated. Meta-Test version 6.0 was adopted in statistical analysis. With the test of heterogeneity, fixed statistical effect model was selected. Subsequently pooled weighted sensitivity, specificity, positive predictive value, negative predictive value were analyzed, and the corresponding 95%CI were calculated. Summary receiver operating characteristic (SROC) curve was performed and the area under the curve (AUC) was calculated. Finally, a sensitivity analysis was performed. Results Nine study met inclusion criteria. The pooled sensitivity, specificity, positive predictive value, negative predictive value and the corresponding 95%CI were 93% (89%-96%), 78%( 70%-85%), 90% (86%-93%) and 85%(76%-91%). The accordance rate was 90.21% comparing with the pathological result. Conclusion FDG-PET is an accurate noninvasive imaging test for diagnosis of SPNs, with high sensitivity and intermediate specificity for malignancy. [
出处
《中国医学影像技术》
CSCD
2004年第11期1754-1756,共3页
Chinese Journal of Medical Imaging Technology
