摘要
目的 探讨介入化疗在巨块型子宫颈癌的应用。方法 研究对象为 10 0例Ⅰb～Ⅲa期子宫颈癌患者 ,化疗药物为DDP(或铂尔定 ) +E -ADM。DDP 5 0mg/m2 ,铂尔定 30 0mg/m2 ,E ADM 4 5mg/m2 。采用Seldinger经皮穿刺插管方法灌注双侧髂内动脉。结果 总有效率为 87.0 % ,73例患者进行了子宫根治术 +盆腔淋巴结清扫术。术中出血减少 ,手术时间缩短。主要的不良反应为恶心、呕吐和白细胞降低。结论 此方法可为巨块型宫颈癌及宫旁有浸润的不能手术的大部分子宫颈癌患者行子宫根治术创造条件并降低手术难度。
Objective To evaluate the effects of intraarterial chemotherapy for bulky uterine cervical carcinoma. Methods One hundred untreated patients with stage Ⅰb-Ⅲa uterine cervical carcinoma were included in the study. Intraarterial chemotherapy was undertaken with a combination of Cisplatin (DDP) 50 mg/m 2 or Paraplatin 300 mg/m 2, Epiadriamycin (E-ADM)45 mg/m 2 one time/2ws. Results The overall response rate was 87.0%. Radical hysterectomy was performed in 73 patients with less bleeding and shorter operative time than those of untreated group. The major adversary effects were leukocytopenia, nausea, and vomiting. Conclusions Intraarterial chemotherapy is effective for preoperative treatment of uterive cesrvical cances with easier radical hysterectomy, especially for inoperable bulky ones.
出处
《介入放射学杂志》
CSCD
2004年第6期530-531,共2页
Journal of Interventional Radiology
