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胰高血糖素样肽-1——2型糖尿病治疗的新策略 被引量：4

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摘要 胰高血糖素样肽-1(GLP-1)由胰岛α细胞和肠道L细胞分泌,具有葡萄糖依赖性促胰岛素分泌、抑制胰高血糖素产生、增加β细胞数量及延缓胃排空等作用。易被二肽基肽酶Ⅳ(DPP-Ⅳ)降解,半衰期(t12)仅数分钟。近来,GLP-1类似物和DPP-Ⅳ抑制剂的研发为2型糖尿病的治疗提供了新策略。
作者 王育璠 彭永德
机构地区 上海交通大学附属第一人民医院内分泌科
出处 《世界临床药物》 CAS 2004年第12期718-721,共4页 World Clinical Drug
关键词 治疗 胰高血糖素样肽-1 2型糖尿病 GLP-1 胃排空 延缓 Β细胞 策略 DPP 增加
分类号 R587 [医药卫生—内分泌] R759.1 [医药卫生—皮肤病学与性病学]
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参考文献10

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同被引文献33

  • 1刘惠侠,曾璐琳.新型降糖药exenatide的研究进展[J].世界临床药物,2005,26(11):691-694. 被引量：8
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世界临床药物
2004年 第12期

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