摘要
缺血性中风患者血清抗心磷脂抗体检测及其临床意义许贻白，诸金水，张国屏，沈翠芬（湖州市第二人民医院神经内科，湖州３１３０００）１９８３年Ｈａｒｒｉｓ等［１］首次用放免法测定抗心磷脂抗体（ＡＣＡ），并证明其和系统性红斑狼疮（ＳＬＥ）并发血栓形成有关，近年...
AbstractIn 70 patients with ischemic
cerebrovascular disease(ICVD) level of serum anticardi olipin
antibodies(ACA)were determined by enzyme-linked immunosorbent
assay,and plas ma lupus anticoagulant by activated partial
thromboplastine time.22 patients with nonis chemic neurologic
disorders(NIND) and 35 healthy subjects were taken as controls.
Results showed that the mean binding index of IgM ACA of patients
with ICVD was significantly higher than those of patients with NIND
and healthy controls(0.99± 0.34 vs 0.71±0.28,0.61±0.14). 16
patients(22.86%)had positive ACA: 14 patients for IgM ACA and 2 for
IgG ACA,about 50% of these patients associated positive ACA had
positive LAC, 25%pa tients associated positive ACA had no other
stroke risk factors or heart diseases. It suggest ed that ACA was
related to ICVD and appeared to be a risk factor for ischemic stroke.
Data from this study showed that ACA associated patients shared
several clinical characteristics:these patients were predominantly
female,frequently in younger individuals,more likely to have
recurrent or multiple infarcts, vertebrobasilar ischemia more often
and particularly co existed with cardiac disease. Potential
mechanisms of ACA in the pathogenesis of cerebral is chemia and its
relation to fibrinolytic coagulant system were discussed briefly.
出处
《中国神经免疫学和神经病学杂志》
CAS
1995年第2期101-104,共4页
Chinese Journal of Neuroimmunology and Neurology
