摘要
基于自然杀伤（ＮＫ）细胞在抗病毒感染及抗肿瘤中的特殊功能及其在免疫调节中的重要作用，本研究采用酶释放试验和流式细胞仪分析技术，检测了一组重症肌无力（ＭＧ）患者周围血中ＮＫ细胞活性和亚群，并研究了免疫治疗对ＮＫ细胞的影响。结果显示ＭＧ患者周围血ＮＫ细胞活性和阳性百分率（１３．９８±８．８８和１１．７６±７．３６）都低于健康对照组（１９．４１±１１．２７和１８．０８±８．０２），尤其是未经治疗者更低（１０．２５±４．５８和１０．９５±５．５０）。胸腺摘除或肾上腺皮质类固醇治疗可提高ＮＫ细胞活性，但对其数量无明显影响。
Because of the important role of natural killer (NK) cells in the immune response of an ti-tumor and anti-viral infection , as well as in immunoregulation,NK cell activity and phenotype of peripheral blood lymphocytes from patients with myasthenia gravis (MG) and healthy controls were studied. We also observed the influences of therapeutic methods on NK cell activity and phenotype. The results showed that both NK cell activity and CD16,CD cells were lower in MG patients (13. 98±8.88 and 11.76±7.36) than in controls (19.41±11.27 and 18.08±8.02),especially in the patients without treatment (10. 25 ±4. 58 and 10. 95±5.50). After treatment by thymectomy or glucocorticoids, NK activity was increased, but the CD16,CD cell percentage was not.
出处
《中国神经免疫学和神经病学杂志》
CAS
1994年第1期32-35,共4页
Chinese Journal of Neuroimmunology and Neurology
基金
卫生部资助课题
