摘要
目的 :探讨雷公藤、防己醇提取物对淋巴细胞和环氧化酶的影响。方法 :测定两种药物的醇提物引起小鼠胸腺淋巴细胞和脾脏淋巴细胞增殖的变化 ,新生小公牛颈动脉内皮细胞的 6 keto PGF1α和小鼠腹腔巨噬细胞的PGE2 含量。结果 :雷公藤和防己醇提物对小鼠胸腺淋巴细胞和脾脏淋巴细胞的增殖有抑制作用。雷公藤醇提物对环氧化酶 1(COX 1)和环氧化酶 2 (COX 2 )有不同程度的抑制作用。防己醇提物对COX 1有抑制作用 ,而对COX 2无抑制作用。结论
Objective: To explore the effects of extracts from Triptergium wilfordii Hook and Stephania tetrandra S. Moore on lymphocytes and cyclooxygenase. Methods: Change in proliferation of mice thymic lymphocytes and spleen lymphocytes, contents of 6-keto-PGF 1α in bovine arterial endothelial cells, PGE 2 in murine macrophages were determined. Results: Proliferation of mice thymic lymphocytes and spleen lymphocytes were inhibited by alcoholic extracts from Triptergium wilfordii Hook, Stephania tertrandra S. Moore. COX-1 and COX-2 were inhibited to different extent by ethanol extracts from Triptergium wilfordii Hook. COX-1 was inhibited by ethanol extracts from Stephania tetrandra S. Moore. Conclusions: Part of anti-rheumatic mechanism of the two herbs might probably be mediating through inhibition of lymphocyte proliferation, COX-1 and COX-2.
出处
《中药材》
CAS
CSCD
北大核心
2004年第11期851-853,共3页
Journal of Chinese Medicinal Materials
基金
广东省中医药管理局资助项目 (10 3 0 5 6)
