摘要
目的 :根据 WHO胸腺上皮性肿瘤 ( TET)分类标准 ,探讨 TET的增殖活性。方法 :采用免疫组织化学法检测胸腺瘤 5 0例 ( A型 5例 ,AB型 10例 ,B1 型 8例 ,B2 型 10例 ,B3型 10例 ,C型 5例 )中 ki- 6 7的表达 ,并计算 ki- 6 7L I%。结果 :1C型胸腺瘤 ki- 6 7L I% ( 2 3.38± 10 .4 2 % )显著高于其它组织学亚型 ;2临床 期 ki- 6 7L I( 2 0 .73± 15 .0 0 % )显著高于临床 期 ( 5 .18± 3.11% )、临床 期 ( 5 .6 9± 2 .2 8% )及临床 期 ( 7.5 8± 5 .85 % )。结论 :ki- 6 7能很好的标记胸腺上皮性肿瘤的增殖活性 ,可以作为临床诊断良。
Objective:To investigate the proliferative activity of thymic epithelial tumors(TET) classified according to World Health Organization histological classification.Methods:50 surgically resected thymic epithel ial tumors(5 Type A, 10 TypeAB, 8 TypeB1, 10 TypeB2, 10 TypeB3,5 TypeC)were selected,and immunohistochemical staining was performed to determine the tumor expression of ki 67, the ki 67 labeling index(LI)of these tumors were evaluated.Results:①Type C thymoma had a higher ki 67 LI(23.38±10.42%)than the other histologica subtypes.②Stage Ⅳ thymoma(20.73±15.00%)had a higher ki 67 LI than Stage Ⅰ(5.18±3.11%)、Stage Ⅱ(5.69±2.28%) and Stage Ⅲ (7.58 ±5.85%) thymoma.Conclusion:Ki 67 was a good indicator of the proliferative activity of thymic epithelial tumors. ki 67 can act as a helpful indicator to distinguish benigh thymoma from malignant thymoma.
出处
《中国误诊学杂志》
CAS
2004年第10期1566-1568,共3页
Chinese Journal of Misdiagnostics
