摘要
用放射免疫分析法检测了44例急性脑梗塞(ACI)病人血浆TXB_2和6—keto-PGF_(1α)含量,发现ACI患者TXB_2含量显著升高,6—Keto-PGF_(1α)含量显著降低。且病灶越大,TXB_2升高越明显,而6—Keto-PGF_(1α)与病灶体积无关。作者认为在治疗ACI时以联合使用PGI_2或类似物及月见草油等抗血小板制剂,对恢复TXA_2/PGI_2的平衡更为合理。
Serial radio-immunoassay was used to determine the plasma TXB_2 and 6KP content in 44 patients with acute cerebral infarction (ACI). Significantly higher TXB_2 and lower 6KP content were found in the ACI patients than those in the controls. We noted the larger the infarction area, the higher the plasma TXB_2 value will be. However, the 6KP content did not correlate with the size of pathological changes. This suggests that it is more reasonable for restoring balance between thromboxane A_2 and prostacyclin when PGI_2 or its analogues, or Evening Primrose Oil, and other antipletelet preparations are combined to treat acute cerebral infarction.
出处
《临床神经病学杂志》
CAS
1993年第3期134-136,共3页
Journal of Clinical Neurology
