摘要
目的比较氟哌利多、胃复安、地塞米松对减少曲马多硬膜外镇痛时恶心呕吐的作用。方法 10 0例ASAⅠ～Ⅱ级行择期妇科手术且接受术后硬膜外自控镇痛患者 ,随机分为 5组 ,每组 2 0例 ,组Ⅰ :氟哌利多 +曲马多 ;组Ⅱ :胃复安 +曲马多 ;组Ⅲ :氟哌利多 +地塞米松 +曲马多 ;组Ⅳ :胃复安 +地塞米松 +曲马多 ;组Ⅴ :生理盐水 +曲马多。观察术后 4、8、12、2 4h的疼痛视觉模拟、恶心呕吐及镇静评分。结果各组术后相同时点平静时疼痛评分无显著差异 (P >0 .0 5 ) ;恶心呕吐评分值组Ⅰ、Ⅱ均小于组Ⅴ ,但无显著差异 (P >0 .0 5 ) ;组Ⅲ、Ⅳ明显低于组Ⅴ (P <0 .0 5 ) ;各组镇静评分无显著差异 (P >0 .0 5 )。结论氟哌利多、胃复安、地塞米松均有一定的镇吐作用 。
Objective To investigate the effects of droperidol,metoclopramide and dexamethasone on postoperative nausea and vomiting(PONV)undergoing epidural analgesia with tramadol. Methods ASA Ⅰ-Ⅱ 100 patients with elective gynecologic surgery were randomly divided into five groups with 20 cases each.Group Ⅰ were given droperidol and tramadol;group Ⅱ were given metoclopramide and tramadol;group Ⅲ were given droperidol and dexamethasone and tramadol;group Ⅳwere given metoclopramide,dexamethasone and tramadol;groupⅤ were given NaCl and tramadol. Postoperative nausea and vomiting,sedation and pain scores were observed at 4,8,12 and 24 h. Results There were no differences among the five groups in scores of pain at the same timepoint.The scores of nausea and vomiting in group Ⅲ and group Ⅳ were lower than that in group Ⅴ(P<0.05).Sedation scores of all groups were similar at all the measured times. Conclusion Droperidol, metoclopramide and dexamethasone given alone can decrease the incidence of nausea and vomiting undergoing epidural analgesia with tramadol.A combined administration can reduce the incidence of nausea and vomiting further.
出处
《上海第二医科大学学报》
CSCD
2004年第11期967-968,共2页
Acta Universitatis Medicinalis Secondae Shanghai
