摘要
目的观察糖尿病人持续输注罗库溴铵后残余肌松的变化。方法选择期腹部手术病人 4 0例 ,分为合并Ⅱ型糖尿病组和非糖尿病组各 2 0例 ,ASAⅡ级。全部病人肌力法肌松监测下 ,罗库溴铵诱导插管 ,吸入 0 .6 %异氟烷 ,并静脉泵注丙泊酚维持BIS 30～ 4 0 ,T1恢复至 15 %开始持续输注罗库溴铵以维持T15 %～ 15 %肌松水平 ,术毕停药后自然恢复 ,观测T1恢复至 2 5 %、5 0 %、75 %和TOF恢复至 70 %的时间及此时的T1/T0 值。结果T12 5 %、5 0 %、75 %恢复时间糖尿病组较非糖尿病组明显延长(P <0 .0 5 ) ,而TOF 70 %恢复时间两组无显著差异 (P >0 .0 5 ) ,其对应T1/T0 值观察组明显低于非糖尿病组 (P <0 .0 1)。结论对糖尿病人全麻术后拔管时机的判断不宜单纯依赖TOF ,应结合T1/T0
Objective To investigate the change of the residual neuromuscular blockade after infusing continuously rocuronium in patients with diabetes mellitus. Methods Forty patients undergoing abdominal surgery were divided into group patients with type2 diabetes mellitus (DM, n=20) and group non-diabetic patients (ND,n=20). After induction, while T 1 recover 15%, all patients began to infuse rocuronium to obtain the depth of neuromuscular block such as T 15%～15%. Record the recovery time of T 125%,50%,75% and TOF 70% by the mechanomyography, as well as simultaneity T 1/T 0. Results There were no significant differences among two groups with patients' information and the time and velocity of infusion rocuronium. Times to recovery of T 125%, 50% and 75% in group DM were significantly longer than in group ND (P<0.05).The times of recovery of TOF 70% were similar in two groups, the simultaneity T 1/T 0 in group DM were significantly lower than in the group ND. Conclusion We should judge the extubation time combining TOF and T 1/T 0 in diabetic patients.
出处
《上海第二医科大学学报》
CSCD
2004年第11期958-960,共3页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
糖尿病
持续输注
罗库溴铵
残余肌松
diabetes mellitus
rocuronium
residual neuromuscular blockade
