摘要
本文归纳整理了近年来三种与耳科学有关的POU结构域家族成员 (POU3F4、POU4F3和POU4F1)的研究状况 ,分别从基因结构、表达方式、作用机制及功能等方面进行综述。
出处
《国外医学（耳鼻咽喉科学分册）》
2004年第6期345-348,共4页
Foreign Medical Sciences(Section of Otolray Ngology Foreign Medical)
参考文献15
-
1Andersen B, Rosenfeld MG. POU Domain Factors in the Neuroendocrine System: Lessons from Developmental Biology Provide Insights into Human Disease. Endocr Rev. 2001; 22: 2-35.
-
2Phippard D, Lu L, Lee D, et al. Targeted mutagenesis of the POU-domain gene Brn4/Pou3f4 causes developmental defects in the inner ear. J Neurosci. 1999; 19: 5980-5989.
-
3Minowa O, Ikeda K, Sugitani Y, et al. Altered cochlear fibrocytes in a mouse model of DFN3 nonsyndromic deafness. Science. 1999; 285:1408-1411.
-
4Malik KF, Jaffe H, Brady J, et al. The class Ⅲ POU factor Brn-4 interacts with other class Ⅲ POU factors and the heterogeneous nuclear ribonucleoprotein U. Brain Res Mol Brain Res. 1997;45: 99-107.
-
5Anagnostopoulos AV. A compendium of mouse knockouts with inner ear defects. Trends Genet. 2002; 18: 499.
-
6Heydemann A, Nguyen LC, Crenshaw EB 3rd. Regulatory regions from the Brn4 promoter direct LACZ expression to the developing forebrain and neural tube. Brain Res Dev Brain Res. 2001; 128: 83-90.
-
7Steel KP, Kros CJ. A genetic approach to understanding auditory function. Nat G enet. 2001; 27: 143-149.
-
8Phippard D, Boyd Y, Reed V, et al. The sex-linked fidget mutation abolishes Brn4/Pou3f4 gene expression in the embryonic inner ear. Hum Mol Genet. 2000; 9: 79-85.
-
9Xiang M, Zhou L, Macke JP, et al. The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. J Neurosci. 1995; 15: 4762-4785.
-
10Xiang M, Gao WQ, Hasson T, et al. Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells. Development. 1998; 125: 3935-3946.
同被引文献3
-
1蒋春梅,易继湖.噪声性听力损失易感基因研究现况[J].环境与职业医学,2007,24(4):417-419. 被引量：4
-
2沈欢喜,李秀婷,朱宝立.谷胱甘肽硫转移酶T1、M1、P1基因多态性与汉族人群职业性噪声聋易感性的关系[J].环境与职业医学,2012,29(5):280-284. 被引量：21
-
3WANG Sheng Li,YU Lu Gang,LIU Ren Ping,ZHU Wan Zhan,GAO Wei Min,XUE Li Ping,JIANG Xu,ZHANG Ya Han,YI Ding,CHEN Dong,ZHANG Yong Hong.Gene-Gene Interaction of GJB2, SOD2, and CAT on Occupational Noise-induced Hearing Loss in Chinese Han Population[J].Biomedical and Environmental Sciences,2014,27(12):965-968. 被引量：13
引证文献1
-
1徐相蓉,杨秋月,何丽华,余善法,焦洁,王菁菁,谷桂珍,陈国顺,周文慧,吴辉,李艳红.POU4F3基因多态性与噪声性高频听力损失易感性的关系[J].环境与职业医学,2016,33(10):959-964. 被引量：1
-
1耳科学[J].中国医学文摘（耳鼻咽喉科学）,2013,28(5):270-270.
-
2陈红清.角朊细胞基因表达的转录调控[J].国外医学（皮肤性病学分册）,1999,25(1):28-32. 被引量：2
-
3王荣光.Adam Politzer与《耳科学历史》[J].国际耳鼻咽喉头颈外科杂志,2011,35(6):364-365.
-
4南京医科大学第一附属医院[J].江苏卫生事业管理,2008,19(6).
-
5顾之燕.耳科学领域中的免疫学(Ⅰ内耳免疫性疾病)[J].中华耳鼻咽喉科杂志,2004,39(1):59-61. 被引量：3
-
6刘爱国,王正敏,周梁.豚鼠颞骨显微解剖学研究[J].解剖科学进展,2003,9(3):224-226. 被引量：8
-
7专题导读[J].中国医学文摘（耳鼻咽喉科学）,2008,23(1):47-47.
-
8王晓燕,叶青,沈帆,谢树森,张先增,詹振林.兔中耳进路及中耳解剖结构的研究[J].山东大学耳鼻喉眼学报,2011,25(6):37-40. 被引量：2
-
9袁永一,戴朴.耳聋基因诊断--转化医学推动耳科学发展的范例[J].中华耳科学杂志,2014,12(1):1-5. 被引量：32
-
10马芙蓉.瑞士苏黎世大学Ugo Fisch教授印象[J].中国医学文摘（耳鼻咽喉科学）,2006,21(6):351-353.
