摘要
目的 观察遗忘型轻度认知损伤 (aMCI)患者服用小剂量多奈哌齐 (商品名 :安理申 )后其认知功能及脑内代谢产物变化 ,以期为痴呆的防治用药探索有效途径。方法 入选 33例aMCI患者 ,治疗组 2 1例服多奈哌齐 2 5mg/d ,连续 3个月 ,对照组 12例 ,两组均维持既往基础用药。用药前后均行临床记忆量表 ,简易智力状态测查 (MMSE) ,词语流畅性及画钟表等认知功能评定 ,并对治疗组中 5例患者分别在用药前后行海马区磁共振质子波谱 (MRS)检查。结果 治疗组用药前后测记忆商 ,MMSE总分以及延迟记忆成绩显著提高 ;MRS检测示用药后海马区N 乙酰基天门冬氨酸 (NAA) /肌酸复合物 (Cr)稳定 ,肌醇 (MI) /Cr升高。结论 小剂量多奈哌齐可有效改善aMCI患者总体认知功能及记忆功能 ;NAA/Cr稳定 ,MI/Cr升高 ,提示多奈哌齐有可能通过星形胶质细胞活化。
Objective To observe the effect of small dose donepezil(Aricept )on the cognition status and the changes of metab olites in brain tissue in patients with amnestic mild cognitive impairment (a MCI)in order to find out the effective way to prevent and cure dementia. Methods 33 patients with aMCI were selected. There were 2 1 cases in a treatment group taking 2.5 mg of Aricept daily for 3 months and 12 cases in a control group taking basic internal medicines. Before and after taki ng the medicine, cognition tests such as clinical memory test, basic IQ test, l anguage fluency test and drawing-clock test were carried out. Before and after treatment, magnetic resonance spectroscopy(MRS) in hippocampus region was carrie d out in 5 patients of the treatment group. Results Compared with the results before treatment, the m emory IQ test, mini-mental state examination (MMSE) total scores as well as del ayed memory scores in the treatment group were improved significantly after trea tment. The difference was statistically significant . MRS results indicated that after treatment NAA/Cr and Cho/Cr in hippocampus region did not change signific antly and MI/Cr was increased. Conclusions 2.5 mg/d of Aricept can improve general cog nition function in patients with aMCI as shown by memory IQ and delayed memory scores. The results of MRS indicate that no apparent chanage of NAA/Cr and incr ease of MI/Cr imply improvement of memory with Aricept through activating astr ocytes, stabilizing neurons and regulating the signal transmission among synapse s.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2004年第10期760-763,共4页
Chinese Journal of Internal Medicine
基金
全军"十五"医药科研重点课题项目资助 ( 0 1Z2 0 3 7)
