摘要
目的 探讨血浆同型半胱氨酸的含量与中青年脑梗死之间的关系以及同型半胱氨酸的影响因素。方法 检测 4 0例中青年脑梗死患者的血浆同型半胱氨酸 (Hcy)、叶酸、VitB12的浓度 ,正常对照组 4 0例。结果 中青年脑梗死患者Hcy高于同年龄健康对照组 (P <0 .0 5 ) ,青年脑梗死患者Hcy高于中年脑梗死患者 (P <0 .0 5 )。中青年脑梗死患者VitB12、叶酸含量均低于同年龄健康对照组 (P <0 0 5 ) ,青年脑梗死患者VitB12、叶酸含量均低于中年脑梗死患者 (P <0 0 5 )。而且Hcy浓度与叶酸、VitB12具有相关性 (P <0 0 5 )。结论 Hcy是脑梗死的一个重要发病因素 ,并且Hcy对青年脑梗死的影响要大于对中年人 ,Hcy的水平与叶酸、VitB12的浓度有关。
Objective To discuss the relationship between plasma homocysteine concentration and the ischemic stroke in young and middle-aged adults,and influence factors of the plasma homocysteine concentration.Method The plasma levels of homocysteine in 40 ischemic stroke in young and middle-aged adilts and 40 healthy controls was measured by high-performance liquid chromatography.Rrsults The plasma homocysteine concentrations in ischemic stroke patients were higher than in controls(P<0.05),and those in young ischemic stroke patients were higher than in middle-aged patients(P<0.05).The levels of folate and VitB12 in ischemic stroke patients were higher than in controls(P<0.05),The plasma homocysteine concentrations have relationship with the levels of folate and VitB12(P< 0.05).Conclusion Homocysteine level is one of the important risk factors to the ischemic stroke,and has more influence to young patients than to middle-aged patients.The folate and VitB12 levels have influence on homocysteine levels.
出处
《中国血液流变学杂志》
CAS
2004年第3期364-365,共2页
Chinese Journal of Hemorheology
关键词
血浆同型半胱氨酸
中青年
脑梗死
影响因素
检测
young and middle-aged adults
ischemic stroke
homocysteine
folate
VitB12
