期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

JNK信号转导通路与糖尿病 被引量：2

暂未订购
导出
摘要 c-jun氨基末端激酶(JNK)是丝裂原活化蛋白激酶(MAPK)家族的成员。JNK信号转导通路参与细胞的胚胎发育、分化、凋亡等。JNK相互作用蛋白-1/(JIP-1)/IB1(islet-brain-1)是哺乳动物JNK信号转导通路的支架蛋白,通过蛋白质之间的相互作用对JNK信号转导通路起关键的调节作用。JNK信号转导通路参与β细胞凋亡、胰岛素基因表达障碍和胰岛素抵抗的发生机制。通过改变细胞中JIP-1的含量等方法抑制JNK的活性或干扰JNK与胰岛素受体底物(IRS)-1的相互作用可成为糖尿病治疗的新靶点。
作者 田景琰 李果
机构地区 上海第二医科大学附属瑞金医院
出处 《国外医学（内分泌学分册）》 2004年第5期329-331,共3页 Foreign Medical Sciences(Section of Endocrinology)
关键词 JNK信号转导通路 糖尿病 JNK 胰岛素抵抗 靶基因
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献18

  • 1Ling Z, Van de Casteele M, Dong J, et al. Variations in IB1/JIP1 expression regulate susceptibility of beta-cells to cytokine-induced apoptosis irrespective of c-Jun NH (2)-terminal kinase signaling. Diabetes,2003,52:2497-2502.
  • 2Aguirre V,Uchida T, Yenush L, et al. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser( 307 ). J Biol C, hem, 2000, 275:9047-9054.
  • 3Ammendrup A, Maillard A, Nielsen K, et al. The e-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells. Diabetes, 2000, 49:1468-1476.
  • 4Widmann C, Gibson S, Jarpe MB, et al. Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev, 1999,79:143-180.
  • 5Bonny C, Oberson A, Steinmann M, et al. IB1 reduces cytokine-induced apoptosis of insulin-secreting cells. J Biol Chem, 2000, 275:16466-16472.
  • 6Haefliger JA, Tawadros T, Meylan L, et al. The scaffold protein IB1/JIP-1 is a critical mediator of cytokine-induced apoptosis in pancreatic beta cells. J Cell Sci,2003,116:1463-1469.
  • 7Bonny C, Oberson A, Negri S, et al. Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Diabetes,2001,50: 77-82.
  • 8Kaneto H, Xu G, Fujii N, et al. Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J Biol Chem, 2002,277: 30010-30018.
  • 9Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature, 2001,410:37-40.
  • 10Hirosumi J, Tuncman G, Chang L, et al. A central role for JNK in obesity and insulin resistance. Nature,2002,420:333-336.

同被引文献26

  • 1钟显飞,蒋明德.c-Jun氨基末端激酶信号转导通路在细胞凋亡中的作用[J].第四军医大学学报,2005,26(16):1533-1534. 被引量：13
  • 2程莹,母义明,汪保安,潘长玉,陆菊明.激活的一磷酸腺苷活化蛋白激酶对软脂酸诱导的血管内皮细胞损伤的保护作用[J].第二军医大学学报,2006,27(9):957-960. 被引量：5
  • 3LUPI R, DOTTA F, MARSELLI L, et al. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated [J]. Diabetes, 2002, 51(5):1437-1442.
  • 4PIRO S, ANELLO M, D1 PIETRO C, et al. Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress[J].Metabolism, 2002, 51(10):1340-1347.
  • 5ABBASI F, CARANTONI M, CHEN YD, et al. Further evidence for a central role of adipose tissue in the anti-hyperglycemic effect of metformin [J].Diabetes Care, 1998, 21:1301-1305.
  • 6PERRIELLO G, MISERICORDIA P, VOLPI E, et al. Acute anti-hyperglycemic mechanisms of metformin in NIDDM, evidence for suppression of lipid oxidation and hepatic glucose production[J].Diabetes, 1994, 43:920-928.
  • 7MARCHETTI P, DEL GUERRA S, MARSELLI L, et al. Pancreatic islets from type 2 diabetic patients have functional defects and increased apotosis that are ameliorated by metformin[J].J Clin Endocrinol Metab, 2004, 89(11): 5535-5541.
  • 8YANG R, TREVILLYAN JM. Trevillyan. C-Jun N-terminal kinase pathways in diabetes[J].Int J Biochem Cell Biol, 2008, 40:2702-2706.
  • 9KEFAS BA, CAI Y, KERCKHOFS K, et al. Metformin-induced stimulation of AMP-activated protein kinase in β-cells impairs their glucose responsiveness and can lead to apoptosis [J].Biochem Pharmacol, 2004, 68:409-416.
  • 10CHAU-VAN C, GAMBA M, SALVI R, et al. Metformin inhibits adenosine 5 '-monophosphate-activated kinase activation and prevents increases in neuropeptide Y expression in cultured hypothalamic neurons [J]. Endocrinology, 2007, 148(2): 507-511.

引证文献2

二级引证文献15

国外医学（内分泌学分册）
2004年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部