摘要
根据中医理论将胃癌、异型增生、肠上皮化生、慢性胃炎各30例进行中医分型,分别为寒热夹杂21例,肝胃不和22例,胃阴不足29例,脾胃虚寒48例。应用 ABC 免疫组化法检测上述标本的 C-myc、p21、p53,以改良 Giemsa 法检测 HP。结果脾胃虚寒型 HP 阳性率(72.9%)与寒热夹杂型阳性率(38.1%)、肝胃不和型阳性率(40.9%)比较有非常显著差异(P<0.01)。C-myc、p21、p53阳性表达与 HP 感染、胃粘膜病变程度呈平行关系,各证型依次为脾胃虚寒>胃阴不足>肝胃不和>寒热夹杂。提示 HP 感染、癌基因及抑癌基因表达与胃癌及癌前病变中医分型有一定关系,有利于辨证辨病分型。
A total of 120 patients with chronic superficial gastritis,intestinal metaplasia,atypical hyperplasia and gastric cancer were divided into,according to basic theories of traditional Chinese medicine,four groups concerning simultaneous occurrence of cold and heat syndrome(group R,n=21), incoordination between the liver and the spleen(group U,n=22),dificiency of the spleen-yin(groupⅠ, n=29)and insufficiency of the spleen-yang(group H,n=48).Expression of C-myc、p21、p53 and PCNA were detected by immunohistochemistry(ABC method),and HP was examined by modified Giemsa. The results showed that group H observed higher occurrences of HP infection(72.9%)than group R (38.1%,P<0.01)and group U(40.9%,P<0.01).Expression of C-myc、p21、p53 were significantly related to HP infection and severities of lesion in gastric mucosa.These oncogenes and tumor suppressor genes were successively expressed,on intensity,in groups H,I,U and R.The findings suggest that HP infection,expression of oncogenes and tumor suppressor were helpful to recognize of the integration of diseases and traditional Chinese medical differentiation of symptoms and signs.
关键词
胃癌
癌前病变
中医分型
HP感染
癌基因
抑癌基因
表达
gastric cancer
precancerosis
traditional Chinese medical types Oncogene
tumor suppressor genes
