摘要
目的:用SD大鼠研究厄多司坦的致畸作用。方法:SD大鼠于妊娠第6～15d灌胃给予厄多司坦,剂量为1g/kg和0.1g/kg,同时设立阴性对照组和阳性对照组,与孕第20d处死动物,进行各项检查。结果:各剂量组孕鼠增重、活胎率、胎鼠体重、身长及尾长与阴性对照组比较,差异皆无显著性(P>0.05);各剂量组胎鼠外观、内脏和骨骼均无畸形发现。结论:在本实验条件下,厄多司坦对SD大鼠无致畸作用。
Purpose: To research the teratogenic effect of Erdosteine on SD rats. Methods: The animals were divided into negative and positive control and two experiment groups which were oraly given by Erdosteine from Day 6 to Day 15 of gestation in dosages of 1.0g/kg and 0.1g/kg respectively. The body growth gains of gestation mice, the numbers, body weight, length and tail length in living fetus and some indicators of embryonic formation were measured. Results: There were no significant differences as compared with negative control groups. Besides, the deformity of the appearances, internal organs and bone in fetal mice was not found. Conclusion: The results indicated that Erdosteine bad no teratogenic effect on SD rats in this experiment.
出处
《中国药品标准》
CAS
2000年第1期17-18,共2页
Drug Standards of China
