摘要
采用放射免疫分析法测定对照组和原发性高血压(EH)组及其治疗前后血浆阿片肽含量变化,并观察阿片肽含量变化与血压值变化间的相互关系。结果表明,与对照组相比,EH组β-内啡肽(β-EP)和亮氨酸脑啡肽(LEK)含量显著下降(P<0.01),强啡肽(Dyn)含量显著上升(P<0.01),EH组经用硝苯吡啶治疗后,三种阿片肽含量显著上升,其中LEK含量变化与平均动脉压(MAP)变化之间有显著相关性(r=0.689,P<0.01)。提示阿片肽与EH之间关系密切,β-EP和LEK含量降低在EH发病机制中占有重要地位。
In this study, radioimmunoassay (RIA) was perfomed to measure the contents of opiate peptide in plasma in control group and essential hypertension (EH) group before and after treatment. The relationship between the changes in opiate peptide content and mean artery pressure (MAP) was analysed. The results showed that the contents of β-endorphin (β-EP) and leuenkephalin (LEK.) in the EH group were lower significantly (P<0.01), while the Dynorphin (Dyn) contents was higher significantly (P<0.01) than those in the control group. After the treatment with Nifedipine, MAP decreased, while contents of three opiate peptide increased clearly, and there was a significant negetive correlation between LEk content and MAP. The above results suggest that there is a close relationship between opiate peptides and EH, suggesting that the changes in opiate peptide content might play an important role in the pathogenesis of EH.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1993年第5期343-345,共3页
Medical Journal of Chinese People's Liberation Army
关键词
高血压
内啡肽
脑啡肽
Essential hypertension
β-endorphin
Dynorphin
Leuenkephalin
