摘要
目的 探讨肺表面活性物质(Curosurf)早期给药对极低出生体重儿呼吸窘迫综合征(MRDS)近期预后的影响。方法 对26例患NRDS的极低出生体重儿给予Curosurf治疗并进行临床对照实验。结果 NRDS患儿给药后12小时Po2/FiO2显著上升,分别为(252.53±49.45)和(184.47±35.04),与给药前比较均P<0.01;比较早期给药组(生后2 h内)和普通治疗组,有创机械通气时间分别为(54.55±11.21)h和(112.00±84.93)h,t=2.217,P<0.05,差异有显著性。患儿体重恢复至出生时水平分别为(11.55±3.70)d和(15.27±4.71)d,t=2.171,P<0.05;贫血出现的时间分别为(21.64±4.48)d和(12.60±4.91)d,t=4.807,P<0.01,差异有显著性;结论 对于极低出生体重儿NRDS,早期给予Curosurf可明显改善近期预后,提高存活率。
Objective To investigate the effect of surfactant in the treatment of neonatal respiratory distress syn dromei(NRDS) in early phase. Methods Twenty - six very low birth weight infants with NRDS were treated with pulmonary surfactant in this controlled clinical trail. Results After administrating surfactant 12 hours, the PO2/FiO2 ascended significantly. Comparison of early and ordinary treatment with Curosurf in neonates, re trieve of weight, appearance of anemia and invaded mechanical ventilation were (11.55±3.70)d and (15.27±4.71)d (21.64±4.48)d, and (12.60±4.91)d, (54.55±11.21)h and (112.00±84.93)h respectively. There were significant difference. Conclusion The strategy of surfactant treatment in early phase can signifi cantly improve the survival of very low birth weight infants with NRDS.
出处
《新生儿科杂志》
2004年第5期210-213,共4页
The Journal of Neonatology
关键词
肺表面活性物质
新生儿
呼吸窘迫综合征
极低出生体重儿
Pulmonary surfactant
Neonatal respiratory distress syndrome
Born very low bith weight infant
