摘要
目的 :探讨 2型糖尿病 (DiabetesMellitus,DM )患者血小板聚集活性与肾微血管病变的关系。方法 :测定 15 6例 2型DM患者血小板功能指标 ,如血小板聚集率、血小板平均体积和肾微血管功能指标 ,如 2 4h尿白蛋白 (Alb)、2 4h尿β2 微球蛋白 ( β2 Microglobulin ,β2 MG)排泄量 ,分析二类指标的相关性。结果 :随着DM患者病情进展 ,尿A1b和尿β2 MG排泄不断增加 ,血小板聚集率逐渐上升 ,血小板平均体积逐渐增大 ,两者成明显正相关。结论 :血小板功能活性升高可能是糖尿病肾脏微血管损伤的促进因素之一 ,抑制血小板过度活化 。
Objective: To explore the association of platelet aggregation function and kidney microvascular complications in type 2 diabetic mellitus(DM).Method: 156 specimens with type 2 DM were measured about platelet function index including platelet aggregation rate,mean platelet volume(MPV) and kidney microvascular function index including 24h urinary Alb and β 2 microglobulin(β 2 MG) excretion amount.Additionally,the relativity between the above two indexes were also analysed.Results: With the development of type 2 DM and the gradually increase of urinary A1b and β 2 MG,the platelet aggregation rate and MPV also rose,which denoted a distinct direct relativity between them.Conclusion: From the experience,that the increase of platelet function activity may be one of the factors that contribute to kidney microangiopathy.Therefore,reducing platelet activity is an important step in treating type 2 DM.
出处
《微循环学杂志》
2004年第4期27-28,共2页
Chinese Journal of Microcirculation
关键词
2型糖尿病
血小板聚集功能
肾微血管病变
并发症
Type 2 diabetes mellitus
Platelet aggregation test
Microalbuminuria
Relativity
