摘要
目的 探讨应用放、化疗粒子联合植入法靶向治疗复发性甲状腺癌的可行性、安全性及短期疗效。方法 应用放、化疗粒子联合植入法靶向治疗甲状腺癌术后放疗后复发病人 9例。在治疗计划指导下 ,经B超引导交替植入 5 氟脲嘧啶 (5 FU)缓释化疗粒子和1 2 5I粒子。结果 9例病人手术成功。术后 6～ 9个月CT复查瘤体不同程度缩小 ,其中 1例完全缓解 ,6例部分缓解 ,2例无变化 ,局部控制率为 78%。随访 8～ 2 6个月 ,现病人全部存活。结论 放射性1 2 5I粒子和 5 FU缓释化疗粒子联合应用局部植入技术是综合治疗复发性甲状腺癌的较有效手段之一。
Objective To investigate the combined treatment technological feasibility,efficacy with interstitial implantation of 125 I seeds and 5-FU slow-release seeds for recurrent thyroid cancer. Methods From March 2002 to December 2003,9 cases of recurrent thyroid cancer were treated with radiochemotherapy. They were all patients with recurrent thyroid cancer after operation and radiation. We implanted alternately 125 I seeds and 5-FU slow-release seeds by guiding of treatment planning system. The MPD of 125 I seed implantation were 60-90 Gy. The mean 8 granules of 125 I seeds and 5-FU 200 mg were used in every patient. Results Fully operating procedure was accomplished for all the patients. No operating complication occurred.No displacement of 125 I seeds was found by cervical X-ray. CT scan showed that the reduced size of tumor changed in different degree. The CR was 11.11%(1/9). The PR was 66.66%(6/9). The NC was 22.22% (2/9). Following up 8-26 months,all patients survived. Conclusion Using radiochemotherapy with interstitial implantation of 125 I seeds and 5-Fu slow-release seeds is safe ,minimally invasive and effective for treatment of recurrent thyroid cancer.
出处
《中华放射医学与防护杂志》
CAS
CSCD
北大核心
2004年第4期346-347,共2页
Chinese Journal of Radiological Medicine and Protection
